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Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury |
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| Authors: | Sigune Peiniger Ulrike Nienaber Rolf Lefering Maximilian Braun Arasch Wafaisade Sebastian Wutzler Matthew Borgmann Philip C Spinella Marc Maegele |
| Affiliation: | (1) Department of Trauma and Orthopedic Surgery, Cologne-Merheim Medical Centre (CMMC), University of Witten/Herdecke, Ostmerheimerstrasse 200, D-51109 Cologne, Germany;(2) Institute for Research in Operative Medicine (IFOM), Cologne-Merheim Medical Centre (CMMC), University of Witten/Herdecke, Ostmerheimerstrasse 200, D-51109 Cologne, Germany;(3) San Antonio Military Medical Center, 3851 Roger Brooke Drive, San Antonio, TX 78234, USA;(4) Department of Pediatrics, Surgical Critical Care, Department of Surgery, Connecticut Children’s Medical Centre (CCMC), 282 Washington Street, Hartford, CT 06106-3322, USA |
| Abstract: | IntroductionRetrospective studies have demonstrated a potential survival benefit from transfusion strategies using an early and more balanced ratio between fresh frozen plasma (FFP) concentration and packed red blood cell (pRBC) transfusions in patients with acute traumatic coagulopathy requiring massive transfusions. These results have mostly been derived from non-head-injured patients. The aim of the present study was to analyze whether a regime using a high FFP:pRBC transfusion ratio (FFP:pRBC ratio >1:2) would be associated with a similar survival benefit in severely injured patients with traumatic brain injury (TBI) (Abbreviated Injury Scale (AIS) score, head ≥3) as demonstrated for patients without TBI requiring massive transfusion (≥10 U of pRBCs). |
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