| 铝对大鼠黑质酪氨酸羟化酶mRNA表达的影响 |
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| 引用本文： | 董大翠,蔡秋云,陈艳贤,王家兵,熊希凯,朱清华.铝对大鼠黑质酪氨酸羟化酶mRNA表达的影响[J].华中科技大学学报(医学版),1999(6). |
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| 作者姓名： | 董大翠 蔡秋云 陈艳贤 王家兵 熊希凯 朱清华 |
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| 作者单位： | 同济医科大学人体解剖学教研室!武汉，430030，同济医科大学人体解剖学教研室!武汉，430030，同济医科大学人体解剖学教研室!武汉，430030，同济医科大学人体解剖学教研室!武汉，430030，同济医科大学人体解剖学教研室!武汉，430030，同济医科大学公共卫生学院营养卫生教研室!武汉，430030 |
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| 基金项目： | 国家自然科学基金!39270519 |
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| 摘 要： | 为了探讨铝对中枢神经系统多巴胺能神经元的影响，采用地高辛标记酪氨酸羟化酶（TH）反义RNA探针原位杂交组织化学方法，观察了氯化铝对大鼠黑质THmRNA表达的影响。结果发现，大鼠服用氯化铝3个月后，黑质背侧部多巴胺神经元THmRNA杂交信号弱于对照组，表明氯化铝对大鼠黑质THmRNA表达有抑制作用。
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| 关 键 词： | 氯化铝 黑质 THmRNA 原位杂交组织化学 |
Effect of Aluminum on Expression of Tyrosine Hydroxylase mRNA in the Rat Nigra |
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| Dong Dacui, Cai Qiuyun, Chen Yanxian et al.Effect of Aluminum on Expression of Tyrosine Hydroxylase mRNA in the Rat Nigra[J].Journal of Huazhong University of Science and Technology(Health Sciences),1999(6). |
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| Authors: | Dong Dacui Cai Qiuyun Chen Yanxian |
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| Abstract: | Effect of Aluminum on the expression of tyrosine hydroxylase (TH) mRNA in the nigra was studied by using in situ hybridization histochemistry with digozigemin-labelled antisence TH cRNA probe.The results showed that after AlCl3 treatment the hybridization signal of TH mRNA of dopamine neurons in the dorsal part of nigra were weaker than in the control group, suggesting that the expression of TH mRNA in the nigra were inhibited significantly by AlCl3. |
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| Keywords: | chloride aluminum nigra tyrosine hydroxylase mRNA in situ hybridization |
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