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| 结合雌激素阴道软胶囊囊皮处方的筛选 | |
| 引用本文： | 赵翡翠,邵晓霞,高晓黎.结合雌激素阴道软胶囊囊皮处方的筛选[J].中国药房,2006,17(21):1611-1613. |
| 作者姓名： | 赵翡翠 邵晓霞 高晓黎 |
| 作者单位： | 1. 新疆医科大学附属中医医院,乌鲁木齐市,830000 2. 新疆克拉玛依市中心医院,克拉玛依市,834000 3. 新疆医科大学药学院,乌鲁木齐市,830054 |
| 摘 要： | 目的:筛选结合雌激素阴道软胶囊(CEVSC)的囊皮处方。方法:通过将囊皮浸泡于内容物中模拟实际压制软胶囊,采用单因素及正交试验,以囊皮溶解速率为指标筛选CEVSC囊皮处方。结果:单因素试验结果表明明胶与甘油及水比例、崩解剂用量、抗氧剂用量是影响囊皮溶解速率的主要因素,正交试验筛选出的囊皮处方中明胶∶甘油∶水为1∶0.6∶1,崩解剂及抗氧剂分别为明胶用量的15%、6%。结论:CEVSC囊皮处方组成合理,可用于工业化生产。 |
| 关 键 词： | 结合雌激素 阴道软胶囊 囊皮处方 筛选 |
| 文章编号： | 1001-0408(2006)21-1611-03 |
| 收稿时间： | 09 25 2006 12:00AM |
| 修稿时间： | 10 9 2006 12:00AM |
Selecting of Capsule Shell Formulation of Conjugated Estrogens Vaginal Soft Capsules |
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| ZHAO Feicui,SHAO Xiaoxia,GAO Xiaoli.Selecting of Capsule Shell Formulation of Conjugated Estrogens Vaginal Soft Capsules[J].China Pharmacy,2006,17(21):1611-1613. | |
| Authors: | ZHAO Feicui SHAO Xiaoxia GAO Xiaoli |
| Institution: | 1.The Affilliated Hospital of TCM of Xinjiang Medical University, Urumqi 830000,China;2.The Kelamayi Central Hospital, Kelamayi 834000, China;3.School of Pharmacy, Xinjiang Medical University, Urumqi 830054, China |
| Abstract: | OBJECTIVE: To select the capsule shell of conjugated estrogens vaginal soft capsules(CEVSC).METHODS: With the dissolution rate of capsule shell as indicators,the orthogonal experiments were conducted to product the soft capsules by soaking capsule shell in contents.RESULTS: The ratio of gelatin,glycerin and water,the volume of disintegrating agents and antioxidants were main factors that influenced the dissolution rate of capsules shell,the results of orthogonal experiments showed that the optimized ratio of gelatin,glycerin and water was 1∶ 0.6∶ 1,the volume of disintegrating agent was 15% of that of gelatin,the oxidant 6%.CONCLUSION: The formula of capsules shell of CEVSC is applicable for industrial production. |
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