| 强直性肌营养不良症19例骨骼肌病理分析 |
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| 引用本文： | 吕海东,李增富,瞿千千,陈芳,秦东香,钱琪,马晓丽,袁利,卢燕婉. 强直性肌营养不良症19例骨骼肌病理分析[J]. 中风与神经疾病杂志, 2010, 27(10) |
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| 作者姓名： | 吕海东 李增富 瞿千千 陈芳 秦东香 钱琪 马晓丽 袁利 卢燕婉 |
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| 作者单位： | 1. 河南省焦作市人民医院神经内科,河南,焦作,454002
2. 郑州大学第一附属医院神经内科,河南,郑州,450052 |
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| 摘 要： | 目的探讨强直性肌营养不良症(DM)骨骼肌病变的病理学特点。方法选择19例经临床和肌电图确诊的强直性肌营养不良症患者为研究对象,骨骼肌标本采用恒冷冰冻切片和酶组织化学染色方法,在光镜下观察骨骼肌组织的病理学变化特点。结果在HE染色,19例患者的骨骼肌标本均可见不同程度的肌纤维萎缩,但变性坏死肌纤维较少见,有7例患者在肌纤维中可见到肌质块。在组织化学MGT染色中,6例患者肌纤维中可见数量不等的破碎红边纤维(RRF),肌质块在MGT染色上呈深绿色,在NADH染色中肌质块呈深蓝色,较HE染色更易识别。在ATP酶染色中,19例患者有11例存在Ⅰ、Ⅱ型肌纤维分布异常现象,其中9例以Ⅰ型纤维明显占优势,2例以Ⅱ型纤维稍占优势,8例患者肌纤维分布基本正常。结论强直性肌营养不良症的骨骼肌病理改变,除常见的肌核增多内移,肌核聚集成核袋及核链现象以外,肌质块的出现和Ⅰ、Ⅱ型肌纤维分布异常应视为强直性肌营养不良症重要的特征性病理改变,肌肉活检对本病的诊断与鉴别诊断有一定的临床意义。
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| 关 键 词： | 强直性肌营养不良症 病理学 肌肉活检 |
Skeletal muscular pathological analysis of myotonic dystrophy in 19 cases |
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| LV Hai-dong,LI Zeng-fu,Qu Qian-qian,et al.. Skeletal muscular pathological analysis of myotonic dystrophy in 19 cases[J]. Journal of Apoplexy and Nervous Diseases, 2010, 27(10) |
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| Authors: | LV Hai-dong LI Zeng-fu Qu Qian-qian et al. |
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| Affiliation: | LV Hai-dong,LI Zeng-fu,Qu Qian-qian,et al.(Department of Neurology,the First People' Hospital of Jiaozuo,Jiaozuo 454002,China) |
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| Abstract: | Objective To study the muscular pathological characteristics in myotonic dystrophy (DM).Methods Nineteen DM patients definitely diagnosed by clinical and electromyographic examination were enrolled in this study.The skeletal muscle samples were stained by histological staining and enzymohistochemistry,and were observed under light microscope for examing the pathological features of muscle tissue.Results The HE staining demonstrated that the degrees of muscle fiber atrophy in all muscle samples were varied.B... |
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| Keywords: | Myotonic dystrophy Pathology Muscle biopsy |
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