Experimental Study of Ultralow-Dose Antibodies to Cyclophosphamide on Cyclophosphamide Myelotoxicity |
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| Authors: | O. I. Epstein A. M. Dygai S. A. Sergeeva V. V. Zhdanov T. Y. Khrichkova L. A. Stavrova G. N. Zyuz’kov E. V. Udut E. V. Simanina |
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| Affiliation: | (1) Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia;(2) Materia Medica Holding, Moscow, Russia |
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| Abstract: | The possibility of using ultralow-dose cyclophosphamide for reducing the myelotoxicity of cyclophosphamide, injected in the maximum permissible dose, was studied in mice. Combined treatment by the cytostatic and its ultralow-dose preparation led to a lesser suppression of the erythroid, lymphocytic, and particularly granulocytic hemopoiesis stems. This effect is explained by stimulation of the secretory activity of hemopoiesisinducing microenvironment and hence, of the functional activity of granulocytopoiesis under the effect of ultralow-dose cyclophosphamide. Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 147, No. 3, pp. 295–299, March, 2009 |
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| Keywords: | myelotoxicity cyclophosphamide ultralow doses hemopoiesis hemopoiesis-inducing microenvironment |
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