| 纳洛酮对IL-1β致热大鼠体温及下丘脑中cAMP和HSP70含量的影响 |
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| 引用本文： | 秦鑫,曹宇,王慧玲,赵红艳,赵书芬. 纳洛酮对IL-1β致热大鼠体温及下丘脑中cAMP和HSP70含量的影响[J]. 中国药理学通报, 2006, 22(10): 1180-1183 |
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| 作者姓名： | 秦鑫 曹宇 王慧玲 赵红艳 赵书芬 |
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| 作者单位： | 中国医科大学基础医学院生理学教研室,辽宁,沈阳,110001 |
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| 摘 要： | 目的研究阿片受体在IL-1β致热大鼠发热过程中的作用及机制。方法经大鼠侧脑室微量注射纳洛酮和(或)IL-1β,观察大鼠体温变化情况,并测定下丘脑中cAMP含量和HSP70表达。结果纳洛酮能够减弱IL-1β致热效应,同时下丘脑中cAMP含量和HSP70表达水平也相应减少(P<0.01)。结论阿片受体拮抗剂纳洛酮能够抑制大鼠IL-1β性发热,其机制可能与降低下丘脑中cAMP的合成有关;同时可见HSP70表达水平降低。
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| 关 键 词： | 发热 纳洛酮 白细胞介素1β- 环磷酸腺苷 热休克蛋白70 |
| 文章编号： | 1001-1978（2006）10-1180-04 |
| 收稿时间： | 2006-05-12 |
| 修稿时间： | 2006-07-22 |
Effects of naloxone on IL-1β-induced fever and the content of cAMP and HSP70 in hypothalamus in rats |
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| QIN Xin,CAO Yu,WANG Hui-ling,ZHAO Hong-yan,ZHAO Shu-fen. Effects of naloxone on IL-1β-induced fever and the content of cAMP and HSP70 in hypothalamus in rats[J]. Chinese Pharmacological Bulletin, 2006, 22(10): 1180-1183 |
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| Authors: | QIN Xin CAO Yu WANG Hui-ling ZHAO Hong-yan ZHAO Shu-fen |
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| Affiliation: | Dept of Physiology, China Medical University, Shenyang 110001 ,China |
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| Abstract: | Aim To study the role and mechanism of opioid receptor on IL-1β-induced fever.Methods Rats were dealed with intracerebreventricular administration of naloxone and/or IL-1β.Changes in body temperature were measured.The content of cAMP and HSP70 expression in hypothalamus were detected.Results Naloxone can limit IL-1β-induced fever and decrease the content of cAMP and HSP70 expression in hypothalamus(P<0.01).Conclusion The present study showed that the opioid receptor antagonist naloxone could inhibit IL-1β-induced fever in rats,and this mechanism might be related with the decrease of cAMP synthesis in hypothalamus;meanwhile the expression of HSP70 was reduced. |
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| Keywords: | fever naloxone IL-1β cAMP HSP70 |
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