| 露点法测定透明质酸钠凝胶渗透压 |
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| 引用本文： | 李乃成,贺艳丽,苏淮,张天民.露点法测定透明质酸钠凝胶渗透压[J].中国生化药物杂志,2008,29(1):56-57. |
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| 作者姓名： | 李乃成 贺艳丽 苏淮 张天民 |
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| 作者单位： | 1. 山东大学药学院,山东济南,250012
2. 山东博士伦福瑞达制药有限公司,山东济南,250014 |
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| 摘 要： | 目的探讨透明质酸钠凝胶渗透压的测定方法。方法用VAPRO 5520渗透压仪分别测定0.5%,1.0%和2.3%透明质酸钠凝胶渗透压;比较0.5%透明质酸钠凝胶称量加样与取样器加样的测定结果。结果0.5%,1.0%和2.3%透明质酸钠凝胶渗透压分别为295,312和330 mOsmol/kg,RSD分别为0.40%,0.18%和0.37%;称量加样与取样器加样测定结果相同。结论VAPRO 5520渗透压仪能准确测定0.5%,1.0%和2.3%透明质酸钠凝胶渗透压。
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| 关 键 词： | VAPRO5520渗透压仪 透明质酸钠凝胶 渗透压 |
| 文章编号： | 1005-1678（2008）01-0056-02 |
| 收稿时间： | 2007-05-30 |
| 修稿时间： | 2007年5月30日 |
Determination of the osmolality of sodium hyaluronate gels by vapor pressure osmometry |
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| LI Nai-cheng,HE Yan-li,SU Huai,ZHANG Tian-min.Determination of the osmolality of sodium hyaluronate gels by vapor pressure osmometry[J].Chinese Journal of Biochemical Pharmaceutics,2008,29(1):56-57. |
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| Authors: | LI Nai-cheng HE Yan-li SU Huai ZHANG Tian-min |
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| Abstract: | Purpose To study a method by which the osmolality of sodium hyaluronate gels can be determined. Methods The osmolality of sodium hyaluronate gels with sodium hyaluronate concentration of 0.5 %, 1.0% and 2.3% respectively were determined by VAPRO 5520 pressure osmometry. The sampling system with pipette or weighing method was compared. Results The osmolality of 0.5 %, 1.0 % and 2.3 % sodium hyaluronate gels was 295,312 and 330 mOsmol/kg and RSD was 0.40 %, 0.18 % and 0.37 % respectively ; The results obtained with pipette and weighing method was the same. Conclusion The osmolality of sodium hyaluronate gels can he determined by VAPRO 5520 pressure osmometry. |
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| Keywords: | VAPRO 5520 pressure osmometry sodium hyaluronate gel osmolality |
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