| 细胞代谢组学及其应用 |
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| 引用本文： | 姚卫峰,周莉娜,张丽,丁安伟,李伟.细胞代谢组学及其应用[J].中国临床药理学与治疗学,2014(3):334-340. |
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| 作者姓名： | 姚卫峰 周莉娜 张丽 丁安伟 李伟 |
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| 作者单位： | [1]南京中医药大学药学院,江苏南京210023 [2]江苏省抗肿瘤验方研究与产业化工程实验室,江苏南京210023 [3]江苏省方剂高技术研究重点实验室,江苏南京210023 |
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| 基金项目： | 国家自然科学青年基金项目资助（81001599）;国家自然科学基金项目资助（81373972）;教育部博士点新教师基金项目资助（20103237120010） |
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| 摘 要： | 细胞代谢组学通常被定义为胞内和细胞膜小分子代谢物的集合，而代谢物参与胞内进程的多种变化，其浓度可近似地反映一个器官、组织或细胞的表型。细胞代谢组学是一个新兴发展的领域，它可解决基本的生物学问题，并允许观察细胞内的代谢现象。在后基因时代，与当前其他常用的方法相比，细胞代谢组学具有许多潜在的优势，已成为一个有前途的分析工具。现简要综述细胞代谢组学的主要研究流程及其应用、与其他组学联用等方面的研究进展。
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| 关 键 词： | 细胞代谢组学 研究流程 组学联用 |
Cell Metabonomics and its Applications |
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| YAO Wei-feng,ZHOU Li-na,ZHANG Li,DING An-wei,LI Wei.Cell Metabonomics and its Applications[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2014(3):334-340. |
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| Authors: | YAO Wei-feng ZHOU Li-na ZHANG Li DING An-wei LI Wei |
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| Institution: | 1 Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu, China ; 2 Engineering Labora-tory of Jiangsu Province for Antitumor Empirical Formula Research and Industrialization, Nan-jing 210023, Jiangsu, China; 3 Jiangsu Key Laboratory for High Technology of TCM Formulae, Nanjing 210023, Jiangsu, China) |
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| Abstract: | Cell metabonomics is often defined as the set of small molecule metabolites in intracellular and membrane.Metabolites are involved in a diverse range of intracellular processes,and their concentrations closely reflect the phenotype of an organism,tissue,or cell.Cell metabonomics is an emerging filed,and it can solve fundamental biological questions and is used to observe metabolic phenomena in cells.In the postgenomics era,cell metabonomics has many potential advantages compared with currently used methods,and it has become a promising analytical tools.This paper briefly reviewed the major research process of cell metabonomics and the progress in application and the integration with other omics. |
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| Keywords: | cell metabonomics research process integration with other omics |
| 本文献已被 CNKI 维普 等数据库收录！ |
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