芜湖市健康体检人群慢性肾脏疾病患病率及相关危险因素调查

目的： 调查芜湖市健康体检人群慢性肾脏病（CKD）患病率以及以及与CKD相关独立危险因素。方法： 40377名芜湖市健康体检居民（男性24164名、女性16213名）入选横断面研究。测量体重、身高和血压，同时检测血常规、尿常规，血脂和肾功能，计算GFR（eGFR）。eGFR＜ 60 ml/min/1.73 m2，和/或蛋白尿、血尿者被定义为CKD。 结果： 芜湖市健康体检人群CKD流行率为6.3%，男性高于女性（7.1% vs 5.0%）。蛋白尿、血尿及eGFR＜ 60 ml/min/1.73 m2 患病率分别为1.7%、2.2%、2.9%，并随着年龄的增长而增长。经年龄、性别校正后，多因素回归分析显示高尿酸血症、糖尿病、贫血、年龄及高血压为CKD相关独立危险因素（优势比（OR）： 2.28, 1.70, 1.65, 1.48, 和 1.29）。结论： 芜湖市城区人口CKD患病率低于国内其他研究报道，芜湖市人群CKD早期防治中要注意上述危险因素。

Prevalence and risk factors for chronic kidney disease in Wuhu

Objectives： We investigated the prevalence of and risk factors associated with chronic kidney disease （CKD） in Wuhu, China. Methods： Clinical data of 40,377 patients undergoing routine checkups at the Yijishan Hospital of Wannan Medical College were analyzed in this cross-sectional study. Blood and urine samples were obtained, and serum creatinine and glomerular filtration rates （eGFR） were calculated. CKD was defined as an estimated glomerular filtration rate of less than 60 ml/min/1.73 m2; the presence of proteinuria and/or hematuria were also considered in the analysis. Results： We found the prevalence of CKD in Wuhu city to be 6.3%. The presence of proteinuria, hematuria, and an eGFR of less than 60 ml/min/m2 were 1.7, 2.2, and 2.9% respectively, all of which increased expectedly with age. After adjusting for gender and age, multivariate analysis demonstrated hyperuricemia, diabetes, anemia, age, and hypertension （OR 2.28, 1.70, 1.65, 1.48, and 1.29, respectively） to be independent risk factors for CKD. Conclusion： CKD in Wuhu city is lower than the average CKD prevalence in China as a whole. The risk factors for CKD outlined above should considered as a potential strategy for the early identification and prevention of CKD.