家族性渗出性玻璃体视网膜病变的眼底分析

目的观察并探讨家族性渗出性玻璃体视网膜病变(FEVR)不同分期的临床眼底表现、造影特征。方法对四川大学华西医院2007年1月至2013年11月确诊为FEVR的15例患者(23只患眼)的临床资料、眼底检查和荧光素眼底血管造影(FFA)报告进行回顾性分析。结果 FEVR 1期1只眼,占4.35%;2期10只眼,占43.48%;3期8只眼,占34.78%;4期1只眼,占4.35%;5期3只眼,占13.04%。眼底检查均可见周边网膜血管分支增多、变细变直,颞侧居多。FFA检查可见近赤道部视网膜血管中止,周边大片无灌注区。结论不同分期FEVR有相应的眼底及FFA改变,全面的眼底检查及家族史采集有助于FEVR的诊断。

Fundus Analysis of Familial Exudative Vitreoretinopathy

Objective To observe and explore the fundus characteristics and fundus fluorescein angiography of familial exudative vitreoretinopathy （FEVR） in different stages. Methods A total of 15 patients （23 eyes） diagnosed as FEVR in the West China Hospital of Sichuan University from January 2007 to November 2013 were included. Clinical data and reports offundus exams and fundus fluorescein angiography （FFA） were retrospectively analyzed. Results One eye （4.35%） was classified as stage I, 10 eyes （43.48%） were classified as stage II, 8 eyes （34.78%） were classified as stage III, and 1 eye （4.35%） and 3 eyes （13.04%） were classified as stage IV and V, respectively. The outcomes of fundus exams showed that the number of peripheral retinal blood vessels increased, and vessels straightened as well as narrowed, especially in the temporal area. FFA showed blood vessels suddenly shut in the equatorial retina and peripheral non-perfusion areas were observed. Conclusion Typical fundus characteristics and fundus fluorescein angiography changes of FEVR can be observed in different stages. Comprehensive fundus exams and family history are helpful to confirm relevant diagnosis.