| 多药耐药相关蛋白1及其与肿瘤关系的研究进展 |
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| 引用本文： | 李俊,蒋葵,张学梅. 多药耐药相关蛋白1及其与肿瘤关系的研究进展[J]. 中国临床药理学与治疗学, 2014, 0(3): 351-355 |
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| 作者姓名： | 李俊 蒋葵 张学梅 |
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| 作者单位： | [1]大连大学医学院,辽宁大连116622 [2]大连医科大学附属第二医院肿瘤科,辽宁大连116027 |
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| 基金项目： | “十一五”国家科技支撑计划项目（2009BAK61B04） |
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| 摘 要： | 多药耐药（MDR）是导致临床肿瘤化疗失败的重要原因。多药耐药相关蛋白1（MRP1/ABCC1）被认为是介导肿瘤多药耐药的主要跨膜转运蛋白之一。 探究MRP1/ABCC1的结构、功能，以及与肿瘤的关系，有利于指导临床合理用药和肿瘤预后的评估。
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| 关 键 词： | 多药耐药相关蛋白1 多药耐药 肿瘤 |
Adervances in the research of multidrug resistance-associated protein 1 and its relationship with tumor |
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| LI Jun,JIANG Kui,ZHANG Xue-mei. Adervances in the research of multidrug resistance-associated protein 1 and its relationship with tumor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 0(3): 351-355 |
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| Authors: | LI Jun JIANG Kui ZHANG Xue-mei |
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| Affiliation: | 1 Medical College of Dalian University, Dalian 116622, Liaoning, China ; 2 Department of Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning ,China) |
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| Abstract: | Multidrug resistance（MDR）is a major impediment to the cancer chemotherapy.Multidrug resistance associated protein 1（MRP1/ABCC1）is thought to be one of the main transmembrane proteins that mediate tumor multidrug resistance.Exploring its structure and function,as well as the relationship between MRP1/ABCC1and tumor,will be beneficial to provide an optimal strategy and evaluate the prognosis of tumor. |
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| Keywords: | multidrug resistance associated protein 1 multidrug resistance tumor |
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