老年急性冠脉综合征患者血清生长分化因子-15的表达及其临床意义 |
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引用本文: | 王乐,李文文,魏梅,刘永升,王庆胜,刘丽.老年急性冠脉综合征患者血清生长分化因子-15的表达及其临床意义[J].实用老年医学,2014(5):380-382. |
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作者姓名: | 王乐 李文文 魏梅 刘永升 王庆胜 刘丽 |
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作者单位: | 秦皇岛市第一医院心内科,河北省秦皇岛市066000 |
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摘 要: | 目的观察生长分化因子-15(GDF-15)在老年急性冠脉综合征(ACS)患者血清中的变化及其对近期预后的预测价值。方法选取老年ACS患者116例,分为急性心肌梗死(AMI)组46例,不稳定型心绞痛(UAP)组70例,同时设同期因胸痛、胸闷症状入院经冠脉造影排除冠心病的对照组40例。采集空腹外周血,采用酶联免疫法测定患者血清GDF-15浓度。对ACS患者随访6月,记录其心血管不良事件的发生情况。结果 AMI组GDF-15水平为(815.41±227.54)ng/L,显著高于UAP组(735.06±144.94)ng/L,P0.05]与对照组(641.97±143.90)ng/L,P0.01]。同时UAP组与对照组GDF-15水平比较差异也有统计学意义(P0.01)。发生心血管事件组GDF-15水平高于未发生心血管事件组(P0.01)。结论 GDF-15水平在老年ACS患者中明显升高,其升高程度与ACS的类型有关,GDF-15可作为判断老年ACS近期预后的指标。
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关 键 词: | 老年人 急性冠脉综合征 生长分化因子-15 |
Serum level and clinical significance of growth differentiation factor-15 in the elderly patients with acute coronary syndrome |
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Institution: | WANG Le, LI Wen-wen, WEI Mei, LIU Yong-sheng, WANG Qing-sheng, UU Li. (Departmera of Cardiology, the First Hospital of Qinhuangdao City, Qinhuangdao 066000, China) |
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Abstract: | Objective To investigate the changes and the short-term prognosis value of growth differentiation factor- 15 (GDF-15)in the elderly patients with acute coronary syndrome(ACS). Methods 116 ACS patients including 46 cases of acute myocardial infarction (AMI) and 70 cases of unstable angina pectoris ( UAP ) were selected. And 40 cases with normal coronary angiography (CAG) were chosen as control group. The serum level of GDF-15 was determined by ELISA. In the meantime, all ACS patients were followed up for six months and the adverse cardiovascular events (ACEs) were recorded. Results The GDF-15 level of AMI group was 815.41±227. 54 ng/L, which was significantly higher than that of UAP group (735.06± 144. 94 ng/L, P〈0. 05) and control group (641.97± 143.90 ng/L, P〈0. 01 ). The level of serum GDF-15 was of significant difference between UAP group and control group (P〈0. 01 ). GDF-15 level was significantly higher in the patients suffering from ACEs(P〈0. 01 ). Conclusions The GDF-15 level is obviously higher in the elderly patients with ACS and is dependent on the type of ACS. The serum level of GDF-15 is associated with short-term prognosis in the elderly patients with ACS. |
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Keywords: | aged acute coronary syndrome growth differentiation factor-15 |
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