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| 采用多因子降维法分析血浆硒水平与D12S304位点与大骨节病发病的交互作用 | |
| 引用本文： | Ping Z,Liu L,Guo X. 采用多因子降维法分析血浆硒水平与D12S304位点与大骨节病发病的交互作用[J]. 卫生研究, 2011, 40(4): 472-3, 477 |
| 作者姓名： | Ping Z Liu L Guo X |
| 作者单位： | 1. 郑州大学公共卫生学院流行病与卫生统计学教研室,郑州,450001 2. 郑州大学基础医学院 3. 西安交通大学医学院环境与疾病相关基因教育部重点实验室 |
| 基金项目： | 国家自然科学基金项目(No.3037125230630058) |
| 摘 要： | 目的采用多因子降维法分析血浆硒水平与D12S304位点的交互作用,研究其与大骨节病发病的关系。方法采用病例—对照设计分析组间血浆硒水平及D12S304位点基因型在组间的差异,采用多因子降维法分析两者的交互作用。结果病例组血浆硒水平低于对照组,而组间基因型无差别,且未发现血浆硒与基因型之间存在交互作用。结论血浆硒与D12S304位点之间暂未发现交互作用,可能需要扩大样本量或选择其它位点进一步探索基因-环境相互作用在大骨节病发生中的机制。 |
| 关 键 词： | 多因子降维 大骨节病 血浆硒 D12S304位点 交互作用 |
Interaction of plasma selenium levels and D12S304 gene site in the pathogenesis of Kashin-Beck disease analyzed by multifactor dimensionality reduction software |
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| Ping Zhiguang,Liu Li,Guo Xiong. Interaction of plasma selenium levels and D12S304 gene site in the pathogenesis of Kashin-Beck disease analyzed by multifactor dimensionality reduction software[J]. Journal of hygiene research, 2011, 40(4): 472-3, 477 | |
| Authors: | Ping Zhiguang Liu Li Guo Xiong |
| Affiliation: | PING Zhiguang,LIU Li,GUO Xiong Department of Epidemiology and Health Statistics,College of Public Health,Zhengzhou University,Zhengzhou 450001,China |
| Abstract: | Objective To explore the interaction of plasma selenium levels and D12S304 gene site in the pathogenesis of Kashin-Beck disease(KBD).Methods Case-control design was taken to compare the difference of plasma selenium levels and genotype of D12S304 between KBD patients and non-patients,and the interactions were analyzed by MDR software.Results Plasma selenium levels was lower in the case group than in the control group,while the D12S304 gene site was not different between the two groups,and no interaction bet... |
| Keywords: | multifactor dimensionality reduction Kashin-Beck disease plasma selenium D12S304 gene site interaction |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |