| 白藜芦醇对C57BL/6J小鼠脂代谢的影响 |
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| 作者姓名： | Ren Y Li Y Zhao Y Yu F Zhan Z Yuan Y Yang J |
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| 作者单位： | 1. 中国医科大学公共卫生学院营养与食品卫生教研室,沈阳,110001
2. 中国医科大学 |
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| 基金项目： | 辽宁省教育厅高校科学基金(No.2009A720) |
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| 摘 要： | 目的观察22.5mg/kg BW白藜芦醇对C57BL/6J小鼠血清和肝脏脂质的影响。方法 30只C57BL/6J雄性小鼠随机分为正常对照组、高脂组和高脂+白藜芦醇组,每组10只,正常对照组喂饲基础饲料,高脂组和高脂+白藜芦醇组喂饲高脂高胆固醇饲料。高脂+白藜芦醇组每日经灌胃给予22.5mg/kg BW白藜芦醇羧甲基纤维素钠溶液进行干预,正常对照组和高脂组均给予0.5%的羧甲基纤维素钠溶液灌胃。干预8周后测定小鼠血清TC、TG、HDL-C和LDL-C水平,肝脏TC和TG水平,并观察小鼠肝组织病理改变。结果高脂组和高脂+白藜芦醇组小鼠血清TC、LDL-C和HDL-C水平均高于正常对照组(P<0.05),高脂组血清TC和LDL-C水平还高于高脂+白藜芦醇组(P<0.05),但高脂组和高脂+白藜芦醇组小鼠血清TG水平均低于正常对照组(P<0.05)。高脂组小鼠肝脏TC水平高于高脂+白藜芦醇组和正常对照组(P<0.05)。结论 22.5mg/kg BW白藜芦醇可以降低喂饲高脂饲料的C57BL/6J小鼠体内胆固醇水平。
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| 关 键 词： | 白藜芦醇 胆固醇 脂质代谢 |
Effects of resveratrol on lipid metabolism in C57BL/6J mice |
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| Ren Y,Li Y,Zhao Y,Yu F,Zhan Z,Yuan Y,Yang J.Effects of resveratrol on lipid metabolism in C57BL/6J mice[J].Journal of Hygiene Research,2011,40(4):495-497. |
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| Authors: | Ren Yahao Li Yanxi Zhao Yue Yu Fei Zhan Zhipeng Yuan Yuan Yang Jun |
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| Institution: | REN Yahao,LI Yanxi,ZHAO Yue,YU Fei,ZHAN Zhipeng,YUAN Yuan,YANG Jun Department of Nutrition and Food hygiene,School of Public Health,China Medical University,Shenyang 110001,China |
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| Abstract: | Objective To investigate the effects of resveratrol on serum and liver lipids in C57BL/6J mice.Methods 30 male C57BL/6J mice were randomly assigned to the following three groups:control group given a normal diet,high-fat diet group and resveratrol group(22.5mg/kg BW) were given high fat diet.the resveratrol were dissolved in 0.5% sodium carboxymethyl cellulose and were given to the Resveratrol group by intragastric administration.The levels of serum total cholesterol(TC),triglycerides(TG),low-density lipopr... |
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| Keywords: | resveratrol cholesterol lipid metabolism |
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