| 苯乙基异硫氰酸盐对不同孕期大鼠的影响 |
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| 引用本文： | Liu H,Zhi Y,Geng G,Yu Z,Xu H. 苯乙基异硫氰酸盐对不同孕期大鼠的影响[J]. 卫生研究, 2011, 40(3): 283-286 |
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| 作者姓名： | Liu H Zhi Y Geng G Yu Z Xu H |
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| 作者单位： | 中国疾病预防控制中心营养与食品安全所,北京,100021 |
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| 基金项目： | “十一五”国家科技支撑计划重大项目(No.2006BAK02A07); 农业部科技行业科技项目(No.200903054-06) |
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| 摘 要： | 目的研究孕期不同阶段给予苯乙基异硫氰酸盐(PEITC)对大鼠受孕的影响及其胚胎毒性作用。方法采用霍恩氏法进行大鼠经口急性毒性实验,分别于孕0～6天(着床前)和孕7～16天(着床后)给予PEITC 0、15、60和120mg/kg,观察孕鼠的一般生理体征,记录体重变化;孕16天(着床前)和孕20天(着床后)观察着床数、活胎数、吸收胎数等,并记录着床点数;称量胎重、胎盘重量和母体的肝脏、肾脏和脾脏重量。结果 PEITC对雌性大鼠的LD50为1.47g/kg;着床前给予PEITC,随着剂量的增加母鼠体重、着床数和活胎数均下降;着床后给予PEITC,随着剂量增加,活胎数下降,吸收胎数上升,且60、120mg/kg组胚胎重量、胎盘重量与对照组均显著性下降;着床前、后PEITC对母体脏器均无显著性毒性作用。结论 PEITC对着床前后孕鼠均具有一定的胚胎毒性,该实验中其对大鼠妊娠的未观察到作用剂量(NOEAL)为15mg/kg。
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| 关 键 词： | 苯乙基异硫氰酸盐 妊娠 胚胎毒性 |
Effect of phenethyl isothiocyanate given at different duration of gestation on the outcome of pregnancy in rats |
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| Liu Haibo,Zhi Yuan,Geng Guiying,Yu Zhou,Xu Haibin. Effect of phenethyl isothiocyanate given at different duration of gestation on the outcome of pregnancy in rats[J]. Journal of hygiene research, 2011, 40(3): 283-286 |
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| Authors: | Liu Haibo Zhi Yuan Geng Guiying Yu Zhou Xu Haibin |
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| Affiliation: | LIU Haibo,ZHI Yuan,GENG Guiying,YU Zhou,XU Haibin Institute of Nutrition and Food Safety,China CDC,Beijing 100021,China |
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| Abstract: | Objective To investigate the effect of phenethyl isothiocyanate(PEITC) on fetal development and embryotoxicity in rats.Methods Acute oral toxicity was conducted by Horn method.PEITC suspended in Tween-80 water was administered orally once a day to pregnant rats in the gestation day 0-6(pre-implantation) and 7-16(post-implantation) at the doses of 15,60 and 120 mg/kg,respectively.On the gestation day 16 or 21,the number of live fetuses,reabsorbed fetuses and implanted sites were counted.The placental weights... |
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| Keywords: | phenethyl isothiocyanate pregnancy embryotoxicity |
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