| 疾病状态下血-脑屏障的病理性开放 |
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| 引用本文： | 郭芮兵,刘新峰. 疾病状态下血-脑屏障的病理性开放[J]. 医学研究生学报, 2005, 18(8): 743-745,750 |
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| 作者姓名： | 郭芮兵 刘新峰 |
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| 作者单位： | 南京大学医学院临床学院(南京军区南京总医院)神经内科,江苏南京,210002 |
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| 基金项目： | 国家自然科学基金资助项目（批准号：30470604）;江苏省自然科学基金（青年科技创新人才技术带头人）资助项目（批准号：BK2004425） |
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| 摘 要： | 血-脑屏障（BBB）可阻止大多数化合物从血液流向大脑，从而维持中枢神经系统（CNS）正常功能。但在疾病状态下，BBB可出现病理性开放，不同疾病引起BBB通透性增高的机制不同。随着BBB研究的快速进展，其破坏机制逐渐被认识，将有助于明确BBB的保护策略并防治与BBB相关的疾病，同时也有助于解决治疗药物通过BBB进入CNS的难题。作者就血-脑屏障病理性开放作一综述。
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| 关 键 词： | 血-脑屏障 疾病 通透性 |
| 文章编号： | 1008-8199（2005）08-0743-03 |
| 收稿时间： | 2005-04-12 |
| 修稿时间： | 2005-04-122005-04-26 |
Pathological opening of blood-brain barrier in disease conditions |
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| GUO Rui-bing,LIU Xin-feng. Pathological opening of blood-brain barrier in disease conditions[J]. Bulletin of Medical Postgraduate, 2005, 18(8): 743-745,750 |
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| Authors: | GUO Rui-bing LIU Xin-feng |
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| Affiliation: | ZengShu;ShenJiao |
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| Abstract: | Most compounds in blood are blocked from flowing into brain by blood-brain barrier(BBB) to keep central nerve system normal, but this barrier will be open in different diseases with different mechanisms. As these mechanisms are understood more and more clearly, it will do help to protect blood-brain barrier and treat diseases which are correlative to blood-brain barrier. At the same time, it may also be helpful to let drugs entering central nerve system through BBB. |
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| Keywords: | Blood-brain barrier Disease Permeability |
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