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Addition of a propyl gallate-based procoagulant to a fibrin bandage improves hemostatic performance in a swine arterial bleeding model |
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| Authors: | Rothwell Stephen W Fudge James M Chen Wan-Keung Reid Thomas J Krishnamurti Chitra |
| Institution: | a Department of Blood Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA b Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, Bethesda, MD, USA c Department of Animal Medicine, Walter Reed Army Institute of Research, Silver Spring, MD, USA |
| Abstract: | Fibrin bandages manufactured by Nycomed Austria (TC-S) were modified by the addition of Hemostyptin (HS), a proprietary platelet-activating reagent containing propyl gallate. HS was added as an additional layer to TC-S fibrin bandages and the bandages were tested for hemostatic efficacy in a swine femoral artery bleeding model. Injuries were treated with a TC-S+HS bandage preparation using HS lyophilized onto a bandage surface that was then attached to the fibrin dressing. This preparation qualitatively and quantitatively exhibited more robust blood clotting at the surgical site than the control bandages. TC-S+HS bandages were more effective than control bandages with a difference in blood loss of 251.8±66.5 g for TC-S bandage alone, n=12 vs. 121±40.7 g, n=13 for the TC-S+HS bandage, P=0.05. Bleeding times were shortened for animals treated with the HS fortified bandages and residual platelets counts in these animals were higher. |
| Keywords: | Fibrin dressing Arterial hemorrhage Swine Fibrinogen Propyl gallate |
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