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| 小鼠皮层eaveolin-1蛋白表达与作业成绩的相关性 | |
| 引用本文： | 连永亮,邹萍,马依妮,王秀文,王佳佳,韩丹女,梁小峰,邹伟.小鼠皮层eaveolin-1蛋白表达与作业成绩的相关性[J].中华行为医学与脑科学杂志,2011,20(10). |
| 作者姓名： | 连永亮 邹萍 马依妮 王秀文 王佳佳 韩丹女 梁小峰 邹伟 |
| 作者单位： | 1. 辽宁师范大学生命科学学院,大连,116029 2. 大连大学师范学院 3. 辽宁师范大学发展心理与教育研究中心 |
| 基金项目： | 国家自然科学基金，辽宁省高校改革项目 |
| 摘 要： | 目的 探讨小鼠作业成绩与皮层中caveolin-1( Cav-1)蛋白表达的相关性.方法 以昆明种小鼠为实验对象,建立y-迷宫模型,根据训练成绩将小鼠分为优良组与不良组,通过Western blot技术检测作业成绩不同的小鼠皮层、海马中Cav-1蛋白的表达并分析与作业成绩的相关性.结果 作业成绩优良组小鼠皮层中Cav-1蛋白的表达(Cav-1/β-actin为5.71±1.11),高于作业成绩不良组(Cav-1/β-actin为1.69±0.20),差异具有显著性(P＜0.01)；而优良组小鼠海马中Car-1蛋白的表达(Cav-1/β-actin为0.22±0.09)与不良组(Cav-1/β-actin为0.26±0.04)相比,差异无显著性(P＞0.05).结论 小鼠y-迷宫作业成绩优劣与脑内皮层中Cav-1蛋白的表达具有明显相关性. |
| 关 键 词： | Caveolin-1:作业成绩 小鼠 皮层 |
The relationship between operation scores and the expression of caveolin-1 protein in the cortex of mice |
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| Authors: | LIAN Yong-liang ZOU Ping MA Yi-ni WANG Xiu-wen WANG Jia-jia HAN Dan-nv LIANG Xiao-feng ZOU Wei |
| Abstract: | Objective To explore the relationship between operation scores and the expression of caveolin-1 ( Cav-1 ) protein in the cortex of mice.Methods Male Kunming mice were used and divided into two groups (excellent group and bad group) according to the training scores after 4 days' Y-maze learning training.The expression of cav-1 protein in cortex and hippocampus of the mice with different scores were measured through Western blot technology.Results Cav-1 protein expression of excellent group( Cav-1/β-actin was 5.71 + 1.11 ) in the cortex was significantly higher than that of the bad group ( Cav-1/β-actin was 1.69 + 0.20) (P ＜ 0.01 ).While there was no significant difference in the two groups in the expression of Cav-1 protein in hippocampus(P ＞ 0.05 ).Conclusion The operation scores have distinct correlation with the expression of Cav-1 protein in the cortex of mice. |
| Keywords: | Caveolin-1 Operation scores Mice Cortex |
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