| 神经丛蛋白A2(PLXNA2)基因多态性与精神分裂症的关联研究 |
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| 引用本文： | 张艳玲,金超,胡晓凤,刘晨星,卢天兰,阮燕燕,张岱,岳伟华.神经丛蛋白A2(PLXNA2)基因多态性与精神分裂症的关联研究[J].中国心理卫生杂志,2011,25(9):710-714. |
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| 作者姓名： | 张艳玲 金超 胡晓凤 刘晨星 卢天兰 阮燕燕 张岱 岳伟华 |
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| 作者单位： | 北京大学精神卫生研究所,卫生部精神卫生学重点实验室(北京大学),北京100191 |
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| 基金项目： | 国家自然科学基金，863专题项目，北京市科技新星计划 |
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| 摘 要： | 目的:探讨神经丛蛋白(PLXNA2)基因与汉族人群精神分裂症的关联。方法:采用DNA测序检测方法,依据ICD-10诊断标准,在735例汉族精神分裂症住院患者和1316例年龄、性别匹配的正常对照者中,探索PLXNA2基因5个单核苷酸多态性(SNP)位点与精神分裂症的关联。结果:PLXNA2基因的4个SNPs位点与精神分裂症关联(均P<0.05);由rs3811383-rs841865-rs2785622组成的单体型ATT及由rs841865-rs752016组成的单体型AC与精神分裂症关联(均P<0.05)。结论:本研究结果提示PLXNA2基因多态性在中国汉族人群中与精神分裂症关联。
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| 关 键 词： | 精神分裂症 神经丛蛋白(PLXNA2)基因 关联研究 |
Association study of Plexin A2 (PLXNA2) gene polymorphisms with schizophrenia |
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| ZHANG Yan-Ling,JIN Chao,HU Xiao-Feng,LIU Chen-Xing,LU Tian-Lan,RUAN Yan-Yan,ZHANG Dai,YUE Wei-Hua Peking University Institute of Mental Health,Key laboratory of Mental Health,Ministry of Health,Beijing ,China.Association study of Plexin A2 (PLXNA2) gene polymorphisms with schizophrenia[J].Chinese Mental Health Journal,2011,25(9):710-714. |
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| Authors: | ZHANG Yan-Ling JIN Chao HU Xiao-Feng LIU Chen-Xing LU Tian-Lan RUAN Yan-Yan ZHANG Dai YUE Wei-Hua Peking University Institute of Mental Health Key laboratory of Mental Health Ministry of Health Beijing China |
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| Institution: | ZHANG Yan-Ling,JIN Chao,HU Xiao-Feng,LIU Chen-Xing,LU Tian-Lan,RUAN Yan-Yan,ZHANG Dai,YUE Wei-Hua Peking University Institute of Mental Health,Key laboratory of Mental Health,Ministry of Health(Peking University),Beijing 100191,China |
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| Abstract: | Objective:To explore the association of the PLXNA2 gene polymorphisms with schizophrenia.Methods: Five single nucleotide polymorphisms(SNPs) of PLXNA2 gene were analyzed in a sample of 735 schizophrenic patients and 1 334 healthy controls of Chinese Han,using direct DNA sequencing method.The diagnoses were made according to the the International Statistical Classification of Diseases and Related Health Problems 10th Revision(ICD-10).Results: Four SNPs were found to be associated with schizophrenia(rs3811383... |
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| Keywords: | schizophrenia plexin A2(PLXNA2) association study |
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