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| 海绵中活性化学成分的研究进展 | |
| 引用本文： | 许嵘,顾琼,汪洪玲,许娇娇,唐生安. 海绵中活性化学成分的研究进展[J]. 现代药物与临床, 2014, 29(12): 1433-1440 |
| 作者姓名： | 许嵘 顾琼 汪洪玲 许娇娇 唐生安 |
| 作者单位： | 1. 泉州医学高等专科学校 药学系,福建 泉州,362011 2. 天津医科大学 药学院 天津市临床药物关键技术重点实验室,天津,300070 3. 天津大学 药物科学与技术学院,天津,300072 |
| 基金项目： | 国家自然科学基金资助项目(81102371)；天津市应用基础及前沿技术研究计划 |
| 摘 要： | 海洋生物海绵的活性化学成分研究一直都是海洋药物研究的焦点。目前，从海绵中发现了大量的具有抗微生物、抗炎、抗肿瘤、抗病毒和免疫调节等活性的化学成分，其按照化学结构类型可分为脂类、大环内酯类、肽类、生物碱类、甾醇类和萜类等，并且有很多化合物已经进入临床研究。对近年来从海绵中发现的活性化学成分进行综述。 |
| 关 键 词： | 海绵 海洋药物 活性化学成分 生物碱类 |
| 收稿时间： | 2014-11-18 |
Research progress on bioactive constituents from marine sponge |
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| XU Rong,GU Qiong,WANG Hong-ling,XU Jiao-jiao and TANG Sheng-an. Research progress on bioactive constituents from marine sponge[J]. Drugs & Clinic, 2014, 29(12): 1433-1440 | |
| Authors: | XU Rong GU Qiong WANG Hong-ling XU Jiao-jiao TANG Sheng-an |
| Affiliation: | Department of Pharmacy, Quanzhou Medical College, Quanzhou 362011, China;Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China;School of Pharmaceutical Science and Technology, Tianjin University, Tianjn 300072, China;Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China;Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China |
| Abstract: | Study on the chemical constituents and biological activities from marine sponge is a hotspot in the research of marine natural products. So far, a lot of bioactive constituents with the biological activities such as antimicrobial, anti-inflammation, antitumor, antivirus, and immunoregulation are found from various kinds of sponge. According to the chemical structure type, they can be divided into lipids, macrolides, peptides, alkaloids, steroids, and terpenoids. And some compounds have entered clinical study. This article reviews the bioactive constituents from the marine sponge in recent years. |
| Keywords: | marine sponge marine drugs bioactive constituents alkaloids |
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