MVD和VEGF蛋白的表达及16层CT动态增强与脑膜瘤复发的关系 |
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引用本文: | 王淳良,万红萍,梅金红,周莉,王珊珊,徐姗,秦兴义. MVD和VEGF蛋白的表达及16层CT动态增强与脑膜瘤复发的关系[J]. 实用临床医学(江西), 2008, 9(11): 88-92 |
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作者姓名: | 王淳良 万红萍 梅金红 周莉 王珊珊 徐姗 秦兴义 |
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作者单位: | [1]南昌大学第一附属医院脑外科,南昌330006; [2]南昌大学第一附属医院病理科,南昌330006; [3]南昌大学第一附属医院影像科,南昌330006 |
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基金项目: | 江西省教育厅科学技术研究项目 |
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摘 要: | 目的探讨脑膜瘤中微血管密度(microvessel density,MVD)和血管内皮生长因子(vascular endothelial growth factor,VEGF)蛋白的表达以及16层CT动态增强扫描与脑膜瘤复发的关系及其l临床应用价值。方法(1)采用MaxVison^TM法分别检测复发组脑膜瘤33例和非复发组脑膜瘤26例的MVD平均值和VEGF蛋白的表达情况;(2)16层超高速螺旋CT机动态增强扫描,测定CT值及到达峰值持续的时间,分析三者与肿瘤复发的相关性。结果(1)非复发组与复发组脑膜瘤的MVD平均值分别为34.2923±17.2422、71.4100±39.4750,复发组明显高于非复发组(P=0.000〈0.05);其中复发组脑膜瘤Ⅰ级与Ⅱ、Ⅲ级的MVD平均值分别为54.7304±25.3080、109.7800±39.6420,Ⅱ、Ⅲ级的MVD平均值明显高于Ⅰ级者(P=0.000〈0.05)。(2)VEGF蛋白表达在复发组脑膜瘤Ⅰ级的阳性率39.13%(9/23)高于非复发组的阳性率11.54%(3/26)(P=0.044〈0.05)。(3)38例VEGF蛋白表达阴性的脑膜瘤中MVD平均值为37.9263±15.2300,21例VEGF蛋白表达阳性的脑膜瘤中MVD平均值为86.0286±28.7464,VEGF蛋白的表达与MVD平均值呈正相关(r=0.7888,P〈0.001)。(4)16层CT动态增强扫描D-T曲线斜率与MVD平均值呈正相关(r=0.33,P〈0.01);峰值持续时间与MVD平均值呈负相关(r=-0.42,P〈0.005)。结论16层CT动态增强扫描与VEGF蛋白和MVD联合检测可作为脑膜瘤手术前、后客观反映其生物学特性的一组重要指标,为脑膜瘤手术后的进一步治疗提供依据。
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关 键 词: | 复发脑膜瘤 16层CT动态增强扫描 VEGF MVD |
The Relationship between Recurrence and MVD、Expression of VEGF、16-slice Helical Computed Tomography Dynamic Enhancement in Meningiomas |
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Affiliation: | WANG Chun-liang, WAN Hong-ping, MEI Jin-hong, ZHOU Li, WANG Shan-shan,XU Shan, QIN Xing-yi(1. Department of Neurosurgery ; 2. Department of Pathology ; 3 Department of Radiology, the First Affiliated Hospital of Nanchang University ,Nanchang 330006,China) |
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Abstract: | Objective To investigate the relationship between recurrence and expression of VEGF,MVD and multislice helical computered tomography (MSCT) dynamic enhancement in meningiomas, and evaluate its clinical usefulness. Methods Thirty-three recurrence and 26 primary meni-Ngiomas were observed the expression of MVD and VEGF by immunohistochemistry MaxVisionTM. The finding of CT dynamic enhancement were reviewed, measuring the slope rate of time dentisy curves(SR-DTC) and time on peak. Results (1)the general average of MVD in the primary and recurrent meningiomas was respectively 34. 292 3±17. 242 2.71. 410 0±39. 475 0.It was significantly higher in the recurrent group(P= 0. 000〈0.05) ;The general average of MVD was respectively 54. 730 4±25. 308 0,109. 780 0±39. 642 0 in the recurrent meningiomas of grade Ⅰand grade Ⅱ, Ⅲ, and it was significantly higher in the recurrent meningiomas of gradeⅡ, Ⅲ (P= 0. 000%0.05). (2) The expression of VEGF was respectively 39.13 % (9/23) and 11.54 % (3/26)in the recurrent meningiomas of gradeⅠand primary meningiomas. The former was higher than the latter(P=0. 044〈0. 05). (3) The general average of MVD was 37. 926 3±15.230 0 in 38 meningiomas which was negative expression of VEGF, while it was 86.028 6±28. 746 4 in 21 meningiomas which was positive expression of VEGF. Expression of VEGF was positively correlated with general average of MVD (r=0. 788 8, P〈0. 001). (4) The slope rate of time dentisy curves (SR-DTC) in 16-slice CT dynamic enhancement of meningiomas was positively correlated with general average of MVD(r=0.33,P〈0.01) ; MVD was negatively correlated with time on peak(r= -0.42 ,P〈0. 005). Conclusion Expression of VEGF,MVD and 16-slice CT dynamic enhancement in meningiomas were examined combined, and they may be an important prediction marker for detecting the clinical pathological characteristics of meningiomas. |
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Keywords: | VEGF MVD |
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