针麻剖腹产术中血浆皮质醇、5-羟色胺、组织胺及前列腺素含量的变化

<正> 针刺镇痛原理研究证实了针刺的信息是通过神经递质和活性物质的传递而产生镇痛效果。在这些递质中有些有利于针刺镇痛,有些不利于针刺镇痛,而同一递质在中枢可能被认为是镇痛物质,在外周则为一致痛物质,其相互间在含量和功能上的平衡是产生针刺镇痛作用的重要条件。为了探讨剖腹产术中的针刺效应与这些物质在外周血中的变化规律,进行了本题研究,总结如下:

CHANGES OF PLASMA CORTISOL,5-HYDROXYTRYPTAMINE,HISTAMINE AND PROSTAGLANDIN F_(2α)DURING CESAREAN SECTION UNDER ACUPUNCTURE ANESTHESIA

The purpose of this study is to investigate the relationship between the effect of acupuncture anesthesia and changes of plasma cortisol,5-hydro- xytryptamine(5-HT),histamine and prostaglandin(PGF).Serial measure- ments of those substances were made at the time of pre-anesthesia,after induction,delivery of newborns and 6 hrs after operation,9 of 18 cases studied were suffered cesarean section under acupunctuue anesthesia and the rest under epidural anesthesia. (1)The basical value of plasma 5-HT and cortisol in patients with acupuncture anesthesia were higher than that of values in epidural anesthesia. However the values of histamine and PGF2α were higher in patients with epidural anestehesia. (2)After inductiod,of acupuncture anesthesia,the average values of 5-HT and PGF2α revealed a slight increase,while the values of histamine were slight decrease.In epidural anesthesia group the level of plasma histamine increased and the others were unchanged. (3)The average of PGF2α was markedly reduced in acupuncture anesthesiu group at the time of delivery of newborn. While in epidural anesthesia group,it was increased. The changes of cortisol in two groups were slight. The average value of cortisol in epidural group vas markedly lover, especially at the time of delivery of nevborn. (4)There vere no significant differents in values of 5-HT,histami e and PGF2α between patients with grade I effectiveness of acupuncture anest- hesia and patients with epidural anesthesia.However,the value of cortisol was significant higher in acupuncture group at all measurements. (5)The comparison between grade Ⅰ and Ⅱ,Ⅲ indicated that there were a significant difference with the value of plasma 5-HT,cortisol,PGF2α at pre-operation,after induction and delivery of newborn.In cases of grade Ⅰ,the value of 5-HT was markedly lower than grade Ⅱ and Ⅲ,while the value of cortisol,PGF2α weere much higher in grade Ⅰ. The results mentioned above suggest that ahere is closed relationship be- tween the values of 5-HT,cortisol,histamine and PGF2α and the effective- ness of acupuncture anesthesia.And also shows a parallel relationship with it.These measurements are able to be objective indices for evaluation and prediction on effectiveness of acupuncture anesthesia and analgesia.