妊娠对卵巢过度刺激综合征影响的探讨

目的分析妊娠对卵巢过度刺激综合征(OHSS)的病程的影响及临床特征。方法回顾性分析广州医科大学附属第三医院2008年1月至2013年12月行超促排卵中发生中、重度OHSS共97例,按是否妊娠,分为未妊娠组(n=40)和妊娠组(n=57),分析两组的平均取卵个数、平均卵巢直径、发病时间、住院时间、各种并发症的发生率等。结果妊娠组的取卵数及平均卵巢直径均较未妊娠组低,差异有统计学意义(P0.05);妊娠组的发病时间较未妊娠组短、住院时间较未妊娠组长,差异均有统计学意义(P0.001)。妊娠组重度OHSS发生率较未妊娠组高,两者比较差异有统计学意义(P0.001)。妊娠组并发胸腹水、血液浓缩、少尿、低蛋白血症、行腹水穿刺的次数显著高于未妊娠组,差异有统计学意义(P0.05)。结论妊娠可以导致OHSS病程迁延,加重病情。

To investigate the effect of pregnancy on the ovarian hyperstimulation syndrome

Objective To analysis the impact and duration of the clinical features of pregnancy in ovarian hyperstimulation syndrome （OHSS）. Methods A retrospective analysis of 97 cases of severe OHSS in the Third Affiliated Hospital of Guangzhou Medical University from January 2008 to November 2013. The 97 cases were divided into non-pregnant group （40 cases ） and pregnant group （57 cases）.The average number of oocytes, the average diameter of the ovary, time of onset, length of stay, and incidence of complications of the two groups were analyzed. Results The mean number of oocytes of the pregnant group wasless than that of the non-pregnant group, and the average diameter of oocytes of the pregnant group were smaller than that of the non-pregnant group; the differences were statistically significant （P〈0.05）. The time after the onset of ovulation ofthe pregnant group was significantly shorter than that non-pregnant group, and the length of staying in hospital of the pregnant group was significantly longer than that of the non-pregnant group（P〈0.001 ）. The incidence of severe OHSS of the pregnant group was significantly higher than that of the non-pregnant group （P〈 0.001）. The incidence of pleural effusion, the blood concentration, the incidence of olignria, hypoalbuminemia patients, ascites puncture of the pregnant group were significantly higher than those of the non-pregnant group （P〈0.05）. Conclusion Pregnancy can lead to prolong of OHSS, and increase the severity of the disease.