PCT、hs-CRP表达量与冠状动脉粥样硬化病变程度的相关性研究

目的探讨冠心病患者血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)表达量与冠状动脉粥样硬化病变程度的相关性。方法 118例冠状动脉造影术患者按造影结果分为冠心病组(n=89)和正常对照组(n=29),随即,采用改良Censini评分方法将冠心病组患者分为30分组(n=24)、30~60分组(n=37)和60分组(n=28),分别检测各组患者PCT和hs-CRP的含量。结果冠心病患者PCT和hs-CRP含量均显著高于对照组,差异有统计学意义(P0.05);同时,冠心病患者PCT和hs-CRP含量随Gensini评分增加而逐渐上升,相关系数分别为0.88和0.90,呈正相关性(P0.05)。结论 PCT、hs-CRP的含量与冠状动脉粥样硬化病变程度呈正相关,联合检测PCT和hs-CRP的含量有助于早期诊断冠状动脉粥样硬化引起的冠心病。

Relationship of combined detection of hs-CRP and PCT and degree of coronary atherosclerosis

Objective To discuss the relationship between the degree of coronary atherosclerosis and the level of hypersensitive C-reactive protein （hs-CRP） and procalcitonin （PCT）. Methods 118 patients with coronary artery angiography were selected for study, including coronary heart disease group （n=89） and normal control group （n=29）. According to the Gensini score system, coronary heart disease（CHD） patients were divided into three groups as 〈30 group （n=24） ,30~60 group （n=37） and 〉60 group （n=28）.hs-CRP and PCT levels were determined and compared between groups and correlated with Gensini score. Results PCT and hs-CRP levels of CHD patients were significantly higher than those of control group （P〈0.05）. At the same time, PCT and hs-CRP levels increase gradually with the increase of Gensini score, with a correlation index of 0.88 and 0.90 （P〈0.05）, respectively. Conclusions PCT and hs-CRP levels are positively associated with the degree of atherosclerotic lesions. Combined detection of PCT and hs-CRP can early diagnose CHD caused by coronary artery atherosclerosis.