| 丙戊酸盐的神经保护作用及其机制的研究进展 |
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| 引用本文： | 李凌云,秦正红,梁中琴. 丙戊酸盐的神经保护作用及其机制的研究进展[J]. 中国药理学通报, 2007, 23(3): 295-298 |
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| 作者姓名： | 李凌云 秦正红 梁中琴 |
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| 作者单位： | 苏州大学医学院药理学教研室,江苏,苏州,215123 |
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| 基金项目： | 江苏省高校自然科学基金 |
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| 摘 要： | 丙戊酸盐(valproate,VPA)是临床治疗双相精神障碍的主要药物,能有效控制患者的躁狂和抑郁症状。近年来研究发现,VPA能拮抗多种损伤因素诱导的神经细胞凋亡,并且与神经细胞发生、增殖、分化和神经营养有关。该文对VPA的神经保护作用及其机制的研究进展作一综述。
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| 关 键 词： | 丙戊酸盐 神经保护 HDAC MEK/MAPK bcl-2 |
| 文章编号： | 1001-1978（2007）03-0295-04 |
| 修稿时间： | 2006-10-27 |
Neuroprotective Actions and Possible Underlying Molecular Mechanisms of Valproate |
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| LI Ling-yun,QIN Zheng-hong,LIANG Zhong-qin. Neuroprotective Actions and Possible Underlying Molecular Mechanisms of Valproate[J]. Chinese Pharmacological Bulletin, 2007, 23(3): 295-298 |
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| Authors: | LI Ling-yun QIN Zheng-hong LIANG Zhong-qin |
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| Affiliation: | Dept of Pharmacology, Soochow University School of Medicine, Suzhou Jiangsu 215123, China |
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| Abstract: | Valproate (VPA) has long been used for the treatment of bipolar mood disorder. VPA is effective in control of mania and depression. Recent studies have demonstrated that VPA has profound neuroprotective effects in against various apoptotic stimuli. Moreover, VPA can promote neurogenesis, neuronal proliferation and differentiation. Although intensive research has been dedicated to VPA′s neuroprotection, the molecular mechanisms by which VPA protects neurons are still not fully understood. In this paper, recent progresses in the study of VPA′s neuroprotection and underlying mechanism are reviewed. |
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| Keywords: | HDAC MEK/MAPK bcl-2 |
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