Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection |
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Authors: | Kerr Alison R Irvine June J Search Jennifer J Gingles Neill A Kadioglu Aras Andrew Peter W McPheat William L Booth Charles G Mitchell Tim J |
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Institution: | Division of Infection and Immunity, IBLS, University of Glasgow, Glasgow G12 8QQ, United Kingdom. |
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Abstract: | Variations in the host response during pneumonia caused by Streptococcus pneumoniae in susceptible (CBA/Ca) and resistant (BALB/c) inbred mouse strains were investigated. Significant differences were detected in survival time, core body temperature, lung-associated and systemic bacterial loads, mast cell numbers, magnitude and location of cytokine production, lung disruption, and ability of isolated lung cells to release the cytokine tumor necrosis factor (TNF) alpha in vitro. Overall, the results indicate that the reduced capacity of CBA/Ca mice to induce rapid TNF activity within the airways following infection with S. pneumoniae may be a factor in their elevated susceptibility to pneumococcal pneumonia. |
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