妊娠早期胎盘绒毛区优势血流与早期自然流产的相关性

目的:使用超声HD-Flow模式观察并验证妊娠早期绒毛区优势血流的存在及变化,并探索其与早期自然流产的关系.方法:对接受体外受精-胚胎移植后成功获得单胎妊娠的女性分别于孕5周、孕7周和孕12～13周行超声检查,测量绒毛区优势血流信号及孕囊、卵黄囊、胎芽和胎心等指标,分析绒毛区优势血流信号随孕龄变化情况;分析该信号长度与...

Correlation between the Predominant Blood Flow in the Chorionic Villi and Early Spontaneous Abortion

Objective: To observe the predominant blood flow in the chorionic villi during early pregnancy using ultrasound HD-Flow modality, and to explore the relationship between its changes and early spontaneous abortion. Methods： In women with singleton pregnancy after in vitro fertilization-embryo transfer (IVF-ET), ultrasound examinations were performed at 5, 7 and 12-13 weeks of gestation to measure the predominant flow signal in the chorionic villi and indicators of the gestational sac, yolk sac, embryo and fetal heartbeat. The changes of the predominant flow signal in the chorionic villi with the gestational age, and the related factors, were analysed. The relationship between the flow signal length and the risk of early miscarriage were analyzed. Results： The presence of the predominant flow in the chorionic villi was confirmed in women who underwent IVF-ET, and the length of flow signal was increased with the increasing gestational age. The detection rate and length of this flow signal were significantly higher in the sustained pregnancy group than those in the early spontaneous abortion group (P<0.001). At 7 weeks of gestation, the risk of early spontaneous abortion in women with flow signal lengths below the 5th percentile was 10.84 times higher than that in women with flow signal lengths above the 5th percentile of the same gestational week (OR=10.84, 95%CI: 6.12-19.22, P<0.001). Conclusions： There is a predominant flow signal in the placental villi region during early pregnancy. The too short length of this signal may suggest an increased risk of early spontaneous abortion.