红细胞悬液与血浆不同比例输注对急性创伤患者凝血功能、纤溶功能及血栓弹力图监测结果的影响

目的 探讨大量输血时,红细胞悬液与血浆不同比例输注对急性创伤患者凝血功能、纤溶功能及血栓弹力图(TEG)监测结果的影响.方法 荣县人民医院收治的120例需要大量输血的患者,按入院24h内输注新鲜冰冻血浆(FFP)与红细胞悬液(SRBC)的比例,以100 ml:1U为比例单位,将患者分为低比例组(FFP:SRBC=1:3...

The effects of different ratios of suspended red blood cell to plasma for infusion on coagulation function,fibrinolytic function and monitoring results of thromboelastogram in patients with acute trauma

Objective Objective To explore the effect of different ratios of suspended red blood cell(SRBC)to plasma for infusion on coagulation function,fibrinolytic function and monitoring results of thromboelastogram(TEG)in patients with acute trauma.Methods A retrospective analysis was performed on the clinical data of 120 patients who needed massive blood transfusion in our hospitals.According to different ratios of fresh frozen plasma(FFP)to SRBC within 24 h after admission(taking 100 ml∶1U as the ratio unit),they were divided into low ratio group(FFP∶SRBC=1∶3,n=32),medium ratio group(FFP∶SRBC=1∶2,n=43)and high ratio group(FFP∶SRBC=1∶1,n=45).The general data,coagulation function,fibrinolytic function and TEG monitoring results were compared among the three groups.Results After 1 day of blood transfusion,prothrombin time(PT),activated partial thromboplastin time(APTT)and protein C(PC)were significantly lower while fibrinogen(FIB),reaction time(R),α-Angle and maximum amplitude(MA)were significantly higher in the medium and high ratio groups than those in the low ratio group(P<0.05).D-dimer(D-D)in the high ratio group was significantly higher than that in the low ratio group and FIB and MA were significantly higher than those in the medium ratio group(P<0.05).Conclusion Increasing plasma concentration during infusion can effectively improve the coagulation function and fibrinolytic function of acute trauma patients,and improve the monitoring results of TEG.