| 表观遗传学在支气管哮喘发病机制中的研究进展 |
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| 引用本文： | 李晓慧,霍如婕,田新瑞. 表观遗传学在支气管哮喘发病机制中的研究进展[J]. 国际呼吸杂志, 2022, 42(3): 233-236. DOI: 10.3760/cma.j.cn131368-20201203-01102 |
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| 作者姓名： | 李晓慧 霍如婕 田新瑞 |
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| 作者单位： | 山西医科大学第二医院呼吸与危重症医学科，太原 030001 |
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| 基金项目： | 山西省重点研发计划(国际合作)(201903D421066)。 |
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| 摘 要： | 气道炎症与气道重塑是支气管哮喘(哮喘)长期反复发作以及病死率逐渐升高的主要原因。近年来，随着对表观遗传学认识的深入，人们逐步发现了表观遗传学在哮喘发生发展中的重要作用。本文综述了DNA甲基化、组蛋白修饰和microRNA基因调控三大表观遗传学在哮喘发病机制中的作用。
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| 关 键 词： | 哮喘 气道重塑 DNA甲基化 组蛋白修饰 微小RNA |
Research progress of epigenetics on bronchial asthma pathogenesis |
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| Li Xiaohui,Huo Rujie,Tian Xinrui. Research progress of epigenetics on bronchial asthma pathogenesis[J]. International Journal of Respiration, 2022, 42(3): 233-236. DOI: 10.3760/cma.j.cn131368-20201203-01102 |
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| Authors: | Li Xiaohui Huo Rujie Tian Xinrui |
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| Affiliation: | (Department of Respiratory and Critical Care Medicine,Second Hospital of Shanxi Medical University,Taiyuan 030001,China) |
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| Abstract: | Airway inflammation and airway remodeling are leading cause for long-term repeated attack of bronchial asthma and the gradual increasing fatality rate.In recent years,with the deepening understanding of epigenetics,epigenetics is considered as a major contributor of asthma pathogenesis.This article reviews the roles of the three epigenetics of DNA methylation,histone modification and MicroRNA role in the pathogenesis of asthma. |
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| Keywords: | Asthma Airway remodeling DNA methylation Histone modification microRNA |
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