时差成像技术用于胚胎选择的研究进展

时差成像(time-lapse imaging,TLI)技术是近年来出现的可以实时监控记录胚胎发育过程的新型无创胚胎培养及观察技术.分析TLI记录的形态动力学参数将有助于更全面地评估胚胎质量,以筛选出最优质的胚胎.通过综述性分析国内外已发表的文献,阐述了目前常用的与胚胎发育息息相关的形态动力学参数,并探讨其与胚胎发育潜...

Application of Time-Lapse Imaging Technology for Embryo Selection: A Review

Time-lapse imaging (TLI) is a novel and noninvasive embryo culture and observation technology that can monitor and record the embryonic development in real-time. The analysis of morphokinetic parameters recorded by TLI will help to evaluate the quality of embryos more comprehensively, so as to select the best embryo(s) for embryonic transfer (ET). This review expounds those commonly-used morphokinetic parameters that are closely linked with embryonic development, and discusses the association between these parameters and embryonic development potential and chromosome euploidy. The application status of TLI in embryo selection at present was evaluated, including its advantages and disadvantages. As described in the literature, TLI makes up the flaw of the traditional embryo culture system and morphologic evaluation for embryos, which is helpful for embryologists to select the embryos with developmental potential more accurately. TLI may be the trend of human embryo culture in the future. However, as a new technology, TLI still needs further improvement and perfection, and more research in the embryo selection parameters and embryonic selection models.