| m6A 修饰在免疫系统中的研究进展 |
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| 引用本文： | 陈艺苒,范斌. m6A 修饰在免疫系统中的研究进展[J]. 医学分子生物学杂志, 2022, 19(3): 252-256. DOI: 10.3870/j.issn.1672-8009.2022.03.0013 |
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| 作者姓名： | 陈艺苒 范斌 |
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| 作者单位： | 上海中医药大学附属岳阳中西医结合医院皮肤科 上海市, 200437 |
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| 摘 要： | N6-甲基腺嘌呤 (N6-methyladenosine, m6A) 修饰是 RNA 分子的转录后变化, m6A 最早是上世纪70 年代在细胞 mRNA 上发现的, 但直到全基因组 m6A 定位方法发展后才被广泛研究。 近年来 m6A 在调节mRNA 中的作用及其在各种细胞类型中的功能及其重要性已经得到了证实, m6A 调控多种生理过程中基因表达的机制研究也越来越多。 此综述总结了最近一些关于 m6A 修饰在免疫反应中的作用的研究进展, 讨论了 m6A 修饰在调节先天和适应性免疫反应以及免疫系统发育中的功能。
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| 关 键 词： | m6A RNA 修饰 免疫系统 |
Role of N6-methyladenosine in Immune System |
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| CHEN Yiran,FAN Bin. Role of N6-methyladenosine in Immune System[J]. Journal of Medical Molecular Biology, 2022, 19(3): 252-256. DOI: 10.3870/j.issn.1672-8009.2022.03.0013 |
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| Authors: | CHEN Yiran FAN Bin |
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| Affiliation: | Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200 |
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| Abstract: | N6 -methyladenosine ( m6A) modification is a post-transcriptional change of RNAmolecule. m6A was first discovered in cell mRNA in 1970s, but the extensive investigation on m6Amodification did not begin until the genome-wide m6A localization method was developed. The role ofm6A in regulating mRNA and its functional importance in various cell types have been verified inmany studies, and the mechanism of m6A in regulating gene expression in a variety of physiologicalprocesses has been increasingly studied recently. In this review, we summarized recent advances inm6A modification in immune response, and discussed the regulatory role of m6A modification in innate and adaptive immune responses, and immune system development. |
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| Keywords: | N6-methyladenosine RNA modification immune system |
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