促性腺激素释放激素长方案和拮抗剂方案促排卵冻融胚胎移植周期结局的比较

目的:探讨使用促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)激动剂长方案和GnRH拮抗剂方案促排卵后,冻融胚胎移植(frozen-thawed embryo transfer,FET)周期的妊娠结局和新生儿结局.方法:回顾性分析2016年1月—2020年8月在南京市妇幼保健...

Comparison of Outcomes of Frozen-Thawed Embryo Transfer after GnRH-Agonist Long Protocol and GnRH-Antagonist Protocol

Objective: To compare the clinical outcomes of frozen-thawed embryo transfer (FET) after GnRH-agonist long protocol and GnRH-antagonist protocol. Methods： The clinical data of 10 743 cycles of FET in our center from January 2016 to August 2020 were analyzed retrospectively, including GnRH-antagonist protocol (n=8 304) and GnRH-agonist long protocol (n=2 439). The general information, clinical and neonatal outcomes were compared between the two groups. Results： There were no significant differences in the age, body mass index (BMI), basic FSH level, duration of infertility, type of infertility, parity, endometrial preparation protocol, number of embryos transferred and type of embryos transferred between the two groups (all P>0.05). The dosage of gonadotropin (Gn) used, duration of Gn used, estradiol (E₂) level on hCG day, number of oocytes retrieved and incidence of ovarian hyperstimulation syndrome (OHSS) in the GnRH-agonist long protocol group were significantly higher than those in the antagonist group (all P<0.05). There was no significant difference in the embryo implantation rate, clinical pregnancy rate, early pregnancy loss rate, live birth rate, gestational age and birth weight of singletons and twins between the two groups (all P>0.05). Conclusions： After excluding two factors of the selection of different protocols and the fresh embryo transfer, there was no significant difference in the cycle outcomes of FET between the GnRH-agonist long protocol and GnRH-antagonist protocol while the safety of the GnRH-antagonist protocol was relatively higher.