| 阻塞性睡眠呼吸暂停与静脉血栓栓塞症相关性研究现状 |
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| 引用本文： | 岳芳,杨海珍,胡克. 阻塞性睡眠呼吸暂停与静脉血栓栓塞症相关性研究现状[J]. 国际呼吸杂志, 2022, 42(3): 161-167. DOI: 10.3760/cma.j.cn131368-20210625-00486 |
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| 作者姓名： | 岳芳 杨海珍 胡克 |
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| 作者单位： | 武汉大学人民医院呼吸与危重症医学二科，武汉 430060 |
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| 基金项目： | 国家自然科学基金(81970082);国家重点研发计划项目(2016YFC1304403)。 |
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| 摘 要： | 阻塞性睡眠呼吸暂停(OSA)是多种心血管疾病的重要危险因素。静脉血栓栓塞症是一种常见的慢性致死性疾病，肺血栓栓塞症(肺栓塞)是其突出表现。OSA可致高凝状态，促进静脉血栓栓塞症发生和发展。持续气道正压可改善OSA患者的凝血活性、血小板功能和纤溶系统。然而，需要更多的研究来评估持续气道正压和/或口服抗凝剂治疗能否降低OS...
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| 关 键 词： | 睡眠呼吸暂停，阻塞性 肺栓塞 静脉血栓栓塞 风险 凝血 高凝状态 |
Research status of the correlation between obstructive sleep apnea and venous thromboembolism |
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| Yue Fang,Yang Haizhen,Hu Ke. Research status of the correlation between obstructive sleep apnea and venous thromboembolism[J]. International Journal of Respiration, 2022, 42(3): 161-167. DOI: 10.3760/cma.j.cn131368-20210625-00486 |
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| Authors: | Yue Fang Yang Haizhen Hu Ke |
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| Affiliation: | (The Second Department of Respiratory and Critical Care Medicine,Renmin Hospital of Wuhan University,Wuhan 430060,China) |
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| Abstract: | Obstructive sleep apnea(OSA)is a major risk factor for cardiovascular diseases.Venous thromboembolism is a common chronic fatal disease,and pulmonary embolism is the major expression of venous thromboembolism.OSA may induce a hypercoagulable state that may contribute to the occurrence and development of venous thromboembolism.Coagulation activity,platelet function and fibrinolytic system may improve after continuous positive airway pressure.However,more studies need to be conducted to evaluate how continuous positive airway pressure and/or oral anticoagulation may reduce pulmonary embolism incidence,recurrence,severity and mortality by pulmonary embolism in patients with OSA. |
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| Keywords: | Sleep apnea, obstructive Pulmonary embolism Venous thromboembolism Risk Coagulation Hypercoagulable state |
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