Adrenalectomy alters the response of neurons in the bed nucleus of the stria terminalis to electrical stimulation of the medial amygdala |
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| Authors: | M.Mar Sá nchez ,Fernando Aguado,Fernando Sá nchez-Toscano,David Saphier |
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| Affiliation: | ∗Departments of Pharmacology and Therapeutics, Louisiana State University Medical Center, P.O. Box 33932, 1501 Kings Highway, Shreveport, LA 71130-3932, USA;†Psychiatry, Louisiana State University Medical Center, P.O. Box 33932, 1501 Kings Highway, Shreveport, LA 71130-3932, USA;‡Department of Cellular Biology, Faculty of Medicine, University of Barcelona, Avda. Diagonal s/n, 08036 Barcelona, Spain;§Department of Cellular Biology, Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain |
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| Abstract: | This study was performed to characterize the effects of adrenalectomy (AD)Q on electrical activity and synaptic responses of bed nucleus of the stria terminalis (BNST) and preoptic area (PDA) neurons, which are involved in the control of limbic-hypothalamo-pituitary-adrenocortical (LHPA) activity. Adrenalectomy altered the response of BNST neurons to medial amygdala (AME) stimulation, increasing the proportion of excitatory responses and reducing the number of cells inhibited. No such effects were found for neurons within the PDA. The basal activity of neurons recorded within the BNST and PDA, as well as the latencies and duration of responses, was not af2fected. The specificity of the effects upon BNST, but not POA, neurons suggests that the response of BNST neurons to AME stimulation is corticosteroid dependent, whereas the response of preoptic neurons is not. |
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| Keywords: | Adrenalectomy Hypothalamo-pituitary-adrenocortical axis Bed nucleus of the stria terminalis Preoptic area Medial amygdala Electrophysiology |
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