MRT2弛豫时间定量测定在研究关节软骨生物组织构成中的价值

目的探讨MRT2弛豫时间定量测定在研究关节软骨生物组织构成中的价值。方法20名健康成年男性志愿者和19名骨性关节炎（Osteoarthritis，OA）患者行膝关节矢状位TSE序列8回波扫描，在获得的图像上进行关节软骨B值的测量，分析志愿者软骨浅深层T2值、志愿者与OA患者的T2值之间差异。结果志愿者胫骨面关节软骨浅层的平均B值为（48．8±6．3）ms，深层的平均T2值为（44．3±5．7）ms；股骨面则为（52．1±5．7）ms和（47．7±5．3）ms，差异有统计学意义。（t=3．148和t=3．384，P〈0．01），相应的T2图显示了B值的这种空间分布趋势。OA患者胫骨关节软骨的平均T2值为（56．0±9．1）ms，较健康志愿者膝关节胫骨关节软骨浅层的平均T2值要高，差异有统计学意义（t=3．446，P〈0．01）。结论应用MRT2弛豫时间定量测定可研究关节软骨生物组织构成及其变化，具有临床应用价值。

Discuss the value of T2 relaxation time in the research of femorotibial joint biological tissue

Objective To discuss the value of T2 relaxation time in the research of the biomechanics and function of cartilage of knee joint. Methods Knees of 20 healthy adults and 19 osteoarthritis patients were examined with sagittal 8-echo sequence. The T2 value of cartilage was calculated. The T2 values in the superficial and deeper cartilage of femoral and tibial joint were compared, so did between the osteoarthritis patients and healthy adults. Results The T2 values in the superficial and the deeper tibital cartilage were （48.8±6.3） ms, （44.3±5.7） ms, respectively. The T2 values in the superficial and deeper femoral cartilage were （52.1±5.7） ms, （47.7±5.3） ms, respectively. There was a significant difference between superficial and deeper femoral cartilage （t=3.148 and t=3.384, P 〈 0.01）. The mean T2 value in the tibial cartilage of osteoarthritis patients was （56.0±9.1） ms and was higher than that of healthy adults. There was a significant difference between osteoarthritis patients and healthy adults（ t = 3.446, P 〈 0.01 ）. Conclusion T2 relaxation time can be used in the research of the biomechanics and function of cartilage and has a application value in clinical diagnosis.