不同剂量阿司匹林对冠心病患者C反应蛋白的影响

目的探讨不同剂量阿司匹林(ASP)对冠心病(CHD)患者血浆C反应蛋白(CRP)的影响。方法120例CHD患者根据ASP用量随机分为50mg、100mg、300mgASP治疗组。观察在ASP治疗后1周、2周、4周及12周CRP浓度的变化。结果CHD患者血浆CRP水平明显增高,与正常对照组相比,差异有统计学意义(P<0.01)。ASP100和300mg组用药2周和1周后,CRP浓度有明显下降,与治疗前相比,差异有统计学意义(P<0.01,P<0.05)。结论ASP可显著降低CHD患者血浆CRP含量。

Effect of different dosages aspirin on the level of serum c-reactive protein in patients with coronary heart disease

Objective To investigate the different dosages aspirin(ASP) on the level of serum, c-reactive protein(CRP) in patients with coronary heart disease(CHD). Methods 120 patients with a final diagnosis of CHD were randomly divided into three groups treated respectively with 50 mg,100 mg,300 mg ASP. 40 healthy volunteers were used as controls. Serum CRP levels were measured in each group before treatment and at the first week, the second week, the forth week and the twelfth week after treatment with ASP respectively. Results The serum level of CRP in patients with CHD was significantly higher than that of the normal control group (P<0.01=. The serum CRP level in the group that was treated with 50 mg ASP of no statistical significance between before and after treatment (P>0.05),but after one week of treatment with 300 mg ASP and two weeks of treatment with 100 mg ASP, the serum CRP levels were signuificantly lower than before treatment (P<0.01, P<0.05=. Conclusion It is suggested that ASP markedly reduces the serum CRP level in patients with CHD.