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甲亢患者~(131)Ⅰ治疗前血清TGAb和TPOAb含量与早发甲减关系的探讨
引用本文:王超群,杨军,谢彦,杨继文,葛俊亮,程光华. 甲亢患者~(131)Ⅰ治疗前血清TGAb和TPOAb含量与早发甲减关系的探讨[J]. 皖南医学院学报, 2011, 30(1): 25-27. DOI: 10.3969/j.issn.1002-0217.2011.01.008
作者姓名:王超群  杨军  谢彦  杨继文  葛俊亮  程光华
作者单位:皖南医学院附属弋矶山医院,核医学科,安徽,芜湖,241001
摘    要:目的:测定放射性~(131)Ⅰ治疗前甲亢患者血清甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TGAb)水平,探讨其在~(131)Ⅰ治疗后与早发甲减发生的关系。方法:根据~(131)Ⅰ治疗前TPOAb、TGAb的检测结果,将165例患者分成3组:双阴组10例,单阳组26例,双阳组129例,比较各组间早发甲减的发生率;再将双阳组的129例患者,按TPOAb、TGAb滴度水平的高低分成3组:A组66例,B组54例,C组9例,进一步探讨~(131)Ⅰ治疗前TPOAb、TGAb滴度水平的高低与早发甲减的关系。结果:~(131)Ⅰ治疗后的165例患者,各组间早发甲减发生率差异无统计学意义(χ2=1.35,P>0.05)。双阳组的129例患者,按TPOAb、TGAb滴度水平高低分成3组,各组间早发甲减发生率差异无统计学意义(χ2=0.89,P>0.05)。结论:TGAb、TPOAb滴度水平的高低,对于甲亢~(131)Ⅰ治疗后早发甲减的预测参考价值不大。

关 键 词:甲状腺功能亢进症  碘放射性同位素  自身抗体  早发甲减

Correlation between the serum levels of TPOAb and TGAb in patients with hyperthyroidism and the incidence of the early hypothyroidism
WANG Chao-qun,YANG Jun,XIE Yan,YANG Ji-wen,GE Jun-liang,CHENG Guang-hua. Correlation between the serum levels of TPOAb and TGAb in patients with hyperthyroidism and the incidence of the early hypothyroidism[J]. Acta Academiae Medicinae Wannan, 2011, 30(1): 25-27. DOI: 10.3969/j.issn.1002-0217.2011.01.008
Authors:WANG Chao-qun  YANG Jun  XIE Yan  YANG Ji-wen  GE Jun-liang  CHENG Guang-hua
Affiliation:WANG Chao-qun,YANG Jun,XIE Yan,YANG Ji-wen,GE Jun-liang,CHENG Guang-hua Department of Nuclear Medicine,Yijishan Hospital,Wannan Medical College,Wuhu 241001,China
Abstract:Objective:To investigate the correlation between the serum levels of thyroid peroxidase antibody(TPOAb) and thyroglobulin antibody(TGAb) of patients with hyperthyroidism before ~(131)Ⅰtherapy and the incidence of the early hypothyroidism after ~(131)Ⅰ intervention.Methods:By negative or positive results of TPOAb and TGAb,165 patients with hyperthyroidism were divided into groups of negative TPOAb and TGAb(n=10),positive TPOAband TGAb(n=26) and positive both TPOAb and TGAb(n=129),and the incidence of early hypothyroidism was compared among the three groups after ~(131)Ⅰ therapy.Further,the 129 cases with positive TPOAb and TGAb were sub-divided into three groups by level of TPOAb and TGAb,i.e.,group A(n=66),B(n=54) and C(n=9),for examining the relationship of the levels of TPOAb and TGAb before undergoing treatment of early hypothyroidism.Results:There was no significant differences concerning the incidences of early hypothyroidism among three groups(χ2=1.35,P0.05) and the similar results were found in the 3 sub-groups(χ2=0.89,P0.05).Conclusion:The serum levels of TPOAb and TGAb seem to have little implication in estimating the incidence of the early hypothyroidism after ~(131)Ⅰ therapy for patients with hyperthyroidism.
Keywords:hyperthyroidism  iodine radioisopes  auto-antibodies  early hypothyroidism  
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