| 卡维地洛对慢性收缩性心力衰竭患者心功能及血浆脑钠肽的影响 |
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| 引用本文： | 曹晓霞,王安才.卡维地洛对慢性收缩性心力衰竭患者心功能及血浆脑钠肽的影响[J].皖南医学院学报,2011,30(1):31-33. |
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| 作者姓名： | 曹晓霞 王安才 |
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| 作者单位： | 1. 泾县医院,心内科,安徽,泾县,242500
2. 皖南医学院附属弋矶山医院,干部内科,安徽,芜湖,241001 |
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| 摘 要： | 目的:观察卡维地洛对慢性收缩性心力衰竭(CHF)患者心功能、血浆脑钠肽(BNP)的影响。方法:慢性收缩性心力衰竭患者54例,随机分为常规治疗组和卡维地洛组各27例。常规治疗组使用血管紧张素转化酶抑制剂或血管紧张素拮抗剂、利尿药、硝酸酯类药和洋地黄类药,卡维地洛组在常规治疗基础上加用卡维地洛,疗程16周。观察心功能改善并测定治疗前后左心室射血分数(LVEF)、左心室舒张末期内径(LVEDd)和血浆BNP水平。结果:两组心功能均得到显著改善,血浆BNP水平明显下降,卡维地洛组更明显(P<0.05)。卡维地洛组LVEF和LVEDd虽较常规治疗组有所增加和下降,但差异无显著性。结论:在常规治疗心衰基础上加用卡维地洛能更有效地改善心功能和降低血浆BNP水平。
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| 关 键 词： | 卡维地洛 慢性收缩性心力衰竭 脑钠肽 |
Effect of carvedilol on the left ventricular function and plasma natriuretic peptide level in patients with chronic systolic heart failure |
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| CAO Xiao-xia,WANG An-cai.Effect of carvedilol on the left ventricular function and plasma natriuretic peptide level in patients with chronic systolic heart failure[J].Acta Academiae Medicinae Wannan,2011,30(1):31-33. |
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| Authors: | CAO Xiao-xia WANG An-cai |
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| Institution: | CAO Xiao-xia,WANG An-cai Department of Cardiovascular Diseases,Hospital of Jingxian,Jingxian 242500,China |
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| Abstract: | Objective:To investigate the effects of carvedilol on the left ventricular function and plasma level of B-type natriuretic peptides(BNP)in patients with chronic systolic heart failure(CHF).Methods:Fifty-four patients with CHF were equally randomized into conventional therapy and carvedilol group.The former received medication of digoxin,diuretics and ACEI or ARB,and the latter were given carvedilol in addition to conventional therapy for 16 weeks.Determination of the heart function was performed before and ... |
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| Keywords: | carvedilol chronic systolic heart failure B-type natriuretic peptide |
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