The rat vertex-middle latency auditory-evoked potential as indicator of anaesthetic depth: a comparison with evoked-reflex testing |
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| Authors: | Haberham Z L van den Brom W E Venker-van Haagen A J de Groot H N Baumans V Hellebrekers L J |
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| Affiliation: | Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, NL-3508 TD, Utrecht, The Netherlands. z.l.haberham@las.vet.uu.nl |
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| Abstract: | We investigated whether components from the rat Vx-MLAEP could be used to assess depth of anaesthesia induced by propofol. Propofol decreased MLAEP amplitudes and increased latencies. We propose that the P(16)-N(22) wave in the rat MLAEP is similar to the human P1, and that recovery of this wave during propofol anaesthesia correlates with behavioural measures of the regaining of consciousness. |
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| Keywords: | Vertex-MLAEP P1 Pb EEG Anaesthesia Rat Propofol |
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