| 恶性阻塞性黄疸患者外周血淋巴细胞IL－2产生及IL－2R表达 |
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| 引用本文： | 丁显仲,李桦,熊叔陶,张寿熙,吕坤章. 恶性阻塞性黄疸患者外周血淋巴细胞IL－2产生及IL－2R表达[J]. 中国肿瘤临床, 1995, 0(2) |
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| 作者姓名： | 丁显仲 李桦 熊叔陶 张寿熙 吕坤章 |
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| 作者单位： | 同济医科大学附属协和医院普外科 |
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| 基金项目： | 国家自然科学基金,卫生部青年基金 |
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| 摘 要： | 恶性阻塞性黄疸患者术后极易发生感染，甚至脓毒血症。本文研究了恶性阻在性黄疸患者外用血淋巴细胞ＩＬ－２产生及ＩＬ－２Ｒ表达能力的变化。结果显示：阻塞性黄疸患者外周血淋巴细胞ＩＬ－２产生能力明显下降，ＩＬ－２Ｒ表达也明显下降，恶性阻塞性黄疸患者外周血淋巴细胞ＩＬ－２生成能力及ＩＬ－ＺＲ表达受到明显抑制，与良性阻塞性黄疸组相比，差异具有显著性意义（Ｐ＜０．０５）。恶性阻塞性黄疸患者免疫功能明显受抑，可能是其术后易发生感染甚至脓毒血症的重要原因。
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| 关 键 词： | 恶性阻塞性黄疸，白细胞介素2，白细胞介素2受体 |
Alteration of Production and Expression of Peripheral Lymphocyte in Patients with Malignant obstructive Jaundice |
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| Ding Xian-Zhong, LI Hua, Xiong Shu-Tao, et al. Alteration of Production and Expression of Peripheral Lymphocyte in Patients with Malignant obstructive Jaundice[J]. Chinese Journal of Clinical Oncology, 1995, 0(2) |
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| Authors: | Ding Xian-Zhong LI Hua Xiong Shu-Tao et al |
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| Abstract: | Patients with obstructive jaundice in general are highly susceptible to infection.The reason for this are not clear.This study investigated alteration of IL-2 production and IL-2R expression in patients with malignant obstructve jaundice.The results revealed that level of IL-2 production by lymphocytes and IL2R expression of lymphocytes were significantly depressed in patients with obstructiive jaundice.These changes were even more obvious than those with benign obstructive janudice (P<0.05).Critical immunodepression in patients with malignant obstructive jaundice may be the reason for high susceptibility to infection. |
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| Keywords: | Malignant obstructive jaundice Interleukin 2 Interleukin 2R |
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