Involvement of calmodulin in platelet reaction |
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Authors: | J Kambayashi K Morimoto N Hakata T Kobayashi G K
saki |
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Institution: | The Second Department of Surgery, Osaka University Medical School, Osaka 553, Japan |
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Abstract: | Penothiazines, known as selective inhibitors of calmodulin, completely inhibited platelet aggregation and secretion induced by ADP, collagen, epinephrine, thrombin or calcium ionophore. They also completely inhibited aggregation induced by exogenous arachidonate (AA) or a mixture of thromboxane A2 and prostaglandin endoperoxides (TxA2/PG G2,H2). Also, in the presence of these calmodulin inhibitors, the release of AA from platelet phospholipids (PL) was dosedependently inhibited in stimulated platelets. These observations suggest that in platelet reaction, calmodulin is involved in at least two different steps of the reaction: activation of phospholipases and contraction of platelet actomyosin after the formation of TxA2. |
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Keywords: | Author Keywords: platelet calmodulin phenothiazines |
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