| HIV—1及其nef蛋白存在有与正常人组织呈交叉反应的表位 |
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| 引用本文： | 史良如 Schn.,ME. HIV—1及其nef蛋白存在有与正常人组织呈交叉反应的表位[J]. 免疫学杂志, 1991, 7(3): 147-150,165 |
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| 作者姓名： | 史良如 Schn. ME |
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| 作者单位： | 卫生部武汉生物制品研究所(史良如)，同济医科大学附属协和医院(卫丹)，联邦德国Duesseldorf大学医院输血医学研究所(M.E.Schneider，H.Th.Bruesster，P.Wernet)，联邦德国Tuebingen大学有机化学研究所(R.Schauder，F.O.Gombert)，联邦德国Tuebingen大学有机化学研究所(G.Jung) |
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| 摘 要： | 本文报导了从大量抗HIV-1结构蛋白单抗和抗nef肽、nef蛋白单抗中发现的HIV-1及其nef蛋白存在有与正常人组织呈交叉反应的表位。这些单抗的特异性为抗HIV-1 p55+p24;抗gp160+gp120+gp41;抗p18+p27;抗nef蛋白(表位为由LHGM组成的四个氨基酸顺序)及抗nef蛋白肽(表位为由HPE或HPEY组成的氨基酸顺序)。它们与正常人扁桃体中的基质、血管内皮或平滑肌起反应。文中对AIDS病人自身免疫反应性进行了讨论。
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| 关 键 词： | HIV－1 nef蛋白 单克隆抗体 艾滋病 |
Anti-HIV and Anti-nef Protein Monoclonal Antibody Shows Coss Reactivity with Human Tissue |
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| Shi Liangru et al. Anti-HIV and Anti-nef Protein Monoclonal Antibody Shows Coss Reactivity with Human Tissue[J]. Immunological Journal, 1991, 7(3): 147-150,165 |
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| Authors: | Shi Liangru et al |
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| Abstract: | We have produced 48 murin monoclonal anti-HlV-l proteins antibodiest 11 anti-nef peptide (C-terminal cosensus sequence) and 97 anti-nef+ P27 recombinant protein. From it 33 McAbs (1 anti-P24 + P55; 10 anti-P18 + p27; 2 anti-gp160 + EP120 + gp41; 6 anti-nef peptide (C-terminal cosensus sequence) 1 anti-nef peptide 20, 8 anti-nef pep-tide 20/21; 3 anti-nef peptide 21; 2 anti-nef peptide24/23) had crossreactivity with stroma, endothelium or smooth muscle of small blood vessel in normal human tonsil. Some epi-topes of the cross-reactivity were defined. They were LHGM and HPEor HPEY.The significance and role in Multiple-Antigen-Mediated Autoimmunity (MAMA) in AIDS has been discussed. |
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| Keywords: | Monoclonal antibody Anti-HIV-1 Anti-nef protein Anti-nef peptide cross-reaction Epitope |
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