HPV与CIN、宫颈癌的关系探讨

目的探讨人乳头瘤病毒(human papilloma virus,HPV)感染与宫颈上皮内瘤样病变(cervicalintraepithelial neoplasia,CIN)、宫颈癌发生之间的关系。方法回顾性分析1 500例已确诊CIN或宫颈癌的患者,采用聚合酶链反应(PCR)进行HPV分型,通过第2代杂交捕获试验法(HCⅡ)对比低危型HPV6/11和高危型HPV-16、18感染者的年龄和宫颈病变程度。结果年龄渐次升高,感染HPV几率愈高,感染高危型HPV-16、18阳性率与宫颈癌高发呈正相关。结论对妇女作HPV筛查对预防宫颈癌有重要意义。

Exploration on relationship between HPV and CIN, uterine cervix cancer

【Objective】 To explore the relationship between the human papilloma virus(HPV) infection and cervical intraepithelial neoplasia(CIN),uterine cervix cancer.【Methods】 A retrospective analysis was performed in 1 500 patients with cervical intraepithelial neoplasia(CIN) or uterine cervix cancer,in which polymerase chain reaction(PCR) was used for human papilloma virus typing and Hybrid Capture Ⅱ(HC Ⅱ) was used for comparing the age and the degree of cervical lesions between the patients who were infected with HPV 6/11 of low risk type or HPV-16,18 of high risk type.【Results】 The higher the women’s age was,the higher the infection rate of HPV was.Positive correlation existed between the positive rate of HPV-16,18 of high risk type and the high incidence rate of uterine cervix cancer.【Conclusion】 HPV screening is crucial for preventing uterine cervix cancer in women.