| 正交试验法优选酮通颗粒的提取工艺 |
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| 引用本文： | 武夏明,刘田云,刘逢芹,李宏建. 正交试验法优选酮通颗粒的提取工艺[J]. 齐鲁药事, 2008, 27(4): 235-238 |
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| 作者姓名： | 武夏明 刘田云 刘逢芹 李宏建 |
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| 作者单位： | 1. 山东大学药学院,山东,济南,250012
2. 山东省千佛山医院,山东,济南,250014 |
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| 摘 要： | 目的优化筛选酮通颗粒的提取工艺。方法采用正交试验法进行优选,以溶剂量、提取次数、乙醇浓度、提取时间为可变因素,以葛根素、总黄酮醇苷含量及药材提出率为评价指标,筛选出酮通方剂的最佳提取条件。结果最佳提取工艺为以8倍量70%的乙醇回流提取2次,每次1h。结论该提取工艺客观可行、稳定合理、重现性较好,为大批量工业化制备提供了依据。
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| 关 键 词： | 酮通颗粒 正交试验 提取工艺 |
| 文章编号： | 1672-7738(2008)04-0235-04 |
Study on extraction technology for Tongtong Granules by orthogonal design |
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| WU Xia-ming,LIU Tian-yun,LIU Feng-qin,LI Hong-jian. Study on extraction technology for Tongtong Granules by orthogonal design[J]. qilu pharmaceutical affairs, 2008, 27(4): 235-238 |
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| Authors: | WU Xia-ming LIU Tian-yun LIU Feng-qin LI Hong-jian |
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| Abstract: | OBJECTIVE To establish the optimal extraction technology for Tongtong granules.METHODS The orthogonal test was employed for selecting the optimum of extraction technology.The investigation factors were the concentration and volume of alcohol,the time and times of extraction.The evaluation maker were content of puerarin,total Ginkgo flavone glycosides and extraction rate.The contents of active ingredient were detected by HPLC.RESULTS The best extraction condition was as follow:8 times of 70% alcohol,extracted for 2 times,each time for 1h.CONCLUSION The above mentioned extraction technology was feasible,stable,reasonable and replicable,which can provide reference for industrial production. |
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| Keywords: | Tongtong granules orthogonal test extraction technology |
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