Insulin release by glucose anomers in a rat model of non-insulin-dependent diabetes |
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| Authors: | A Niki H Niki I Niki Y Kunoh |
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| Institution: | (1) Department of Internal Medicine, Aichigakuin University School of Dentistry, Japan;(2) Third Department of Internal Medicine, University of Nagoya School of Medicine, Japan;(3) Maruko Pharmaceutical Co., Ltd., Nagoya, Japan |
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| Abstract: | Summary The effects of the  and  anomers of D-glucose on insulin release were studied in a rat model of non-insulin-dependent diabetes, which was induced by streptozotocin injection at 2 days of age. Glucose tolerance of the streptozotocin-treated rats at 8–10 weeks of age was mildly diabetic. Insulin release from the isolated perfused pancreas of the diabetic rats in response to 10 mmol/l -D-glucose was markedly impaired, while insulin response to 10 mmol/l -D-glucose in the diabetic pancreas was only slightly reduced as compared to that in the control pancreas. |
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| Keywords: | Insulin release glucose anomers streptozotocin neonatal rat non-insulin-dependent diabetes pancreas perfusion pancreatic B cell |
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