2Hz和100Hz经皮神经电刺激对大鼠慢性炎症痛治疗作用的比较

目的：观察经皮神经电刺激（TENS）对大鼠慢性炎症痛的治疗作用。方法：以完全福氏佐剂造成单发关节炎大鼠慢性炎症痛模型，以体重、踝周长、跖屈及背屈关节疼痛试验评分为指标，评价多次低频（2Hz)及高频（100Hz)“足三里”穴位对大鼠关节炎的治疗作用。结果：（1）在体重增长速率方面，多次100Hz TENS明显快于2Hz TENS；（2）在缓解关节肿胀方面，100Hz TENS的效果明显优于2Hz TENS;(3)在缓解疼痛方面，100Hz TENS的作用也明显优于2Hz TENS。结论：经皮神经电刺激对慢性炎症痛有治疗作用，但不同频率的治疗作用又有所不同。

Comparison between Therapeutic Effects of Transcutaneous Electrical Nerve Stimulation with the Frequency of 2 Hz and 100 Hz on Chronic Inflammatory Pain in Rats

OBJECTIVE: To observe the effects of repeated transcutaneous nerve stimulation (TENS) with low frequency (2 Hz) and high frequency (100 Hz) on the chronic inflammatory pain. METHODS: The complete Freund's adjuvant was used to make the monoadjuvant arthritis as a chronic inflammatory pain model. The model animals were divided into 3 groups, the 100 Hz TENS group, the 2 Hz TENS group and the control group. The percentage increase of body weight, circumference of ankle, score of flexion pain test and score of extension pain test were used to evaluate the therapeutic effect of TENS. RESULTS: (1) Body weight increasing rate in the 100 Hz TENS group was markedly higher than that in the 2 Hz TENS group and the control group. (2) Circumference of rats' ankle in the 100 Hz TENS group was smaller than that in the 2 Hz TENS and the control group. (3) Repeated 100 Hz TENS showed more effective on pain relief than that of 2 Hz TENS. CONCLUSION: TENS has therapeutic effects on chronic inflammatory pain in rats, and different frequencies yielded different results.