阻塞性睡眠呼吸暂停低通气综合征患者抑郁情绪和认知功能损害的关系

目的 研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者抑郁情绪和认知功能状况,探讨其与多导睡眠监测图主要指标的关系.方法 选择2006年10月至2008年5月就诊、并经多导睡眠图监测确诊的74例OSAHS患者和39例非OSAHS患者(对照组).采用抑郁自评量表评估其抑郁情绪;应用简易智力状态检企量表分别测定其认知功能.结果 OSAHS组抑郁评分[(52.6±8.2)分]明显高于对照组[(39.6±7.0)分,P=0.01],与呼吸紊乱指数(AHI)正相火,与平均血氧饱和度(MSaO_2)和最低血氧饱和度(LSaO_2)负相关(P均<0.01);OSAHS组认知功能评分[(24.5±1.9)分]明显低于对照组[(26.8±1.2)分,P=0.000],与AHI负相关(P<0.01),与MSaO_2和LSao_2正相关(P<0.01).抑郁评分与认知功能评分负相关(r=-0.505,P<0.01).结论 OSAHS患者存在着抑郁情绪障碍和认知功能明显减退,夜间反复发作的低氧血症是两者发生的主要冈素.

Relationship between depression and the function of cognition in patients with obstructive sleep apnea-hypopnea syndrome

Objective To assess the depression and cognition function in patients with severe obstructive sleep apnea (OSAHS) , and to study the relationship between the depression and severity of OSAHS, cognition disorders. Methods A total of 74 OSAHS patients (OSAHS group) and 39 normal controls ( control group) which all diagnosed by polysomnography (PSG) were chosen, and they were assessed the state of depression by self-rating depression scale ( SDS) and for cognition disorders by mini-mental state examination ( MMSE ). Results The score of SDS in OSAHS group was significantly higher than that in the control group(P<0.01). In patients with OSAHS , the score of SDS was positively correlated with apnea hyponea index ( AHI) , which was negatively correlated with mean level of SaO_2 ( MSaO_2 ) and the lowest SaO_2 ( LSaO_2 ) (P<0.01 ). The score of MMSE in OSAHS group was significantly lower than that in the control group, which was negatively correlated with AHI(P<0.01) and positively correlated with MSaO_2 and the lowest LSaO_2(P<0.01 ). The score of SDS was negatively correlated with MMSE( r= -0.505, P<0.01). Conclusion OSAHS patients exit depression and cognition disorders, which was correlation to intermitten hypoxemia in frequently.