p53和雌、孕激素受体在子宫内膜癌的表达及其临床意义

目的:研究p53、ER和PR在子宫内膜癌的表达及其临床意义。方法:应用免疫组化技术对56例子宫内膜癌组织进行检测,结合临床病理学指标进行分析。结果:p53、ER和PR在56例子宫内膜癌的阳性表达率分别是44.6 %,66.1 %和64.3 %。p53的阳性表达率在子宫内膜癌的不同临床分期和组织学分级均有显著性差异(P<0.05)。ER、PR在子宫内膜癌的阳性表达率与组织学分级密切相关,在组织分化好的阳性表达率显著高于组织分化差的阳性表达率(P<0.05)。结论:p53在子宫内膜癌的发生、发展中起着重要的调控作用。ER、PR的缺失表达与子宫内膜癌的恶性程度密切相关,对分析子宫内膜癌的预后和指导临床内分泌治疗均有重要意义。

Expression and Clinical Significance of p53,ER and PR in Endometrial Carcinoma

Objective: To study the expression and clinical significance of p53, ER and PR in endometrial carcinoma. Methods: 56 cases of endometrial carcinoma were examined by immunohistochemical two stages method for p53, ER and PR. Results: The positive rates of p53, ER and PR is 44.6 %,66.1 % and 64.3 %.p53 expression was correlated with both clinical stage and histologic differentiation. Both ER and PR were correlated with histologic differentiation. Conclusion: p53 may play an important role in the development of endometrial carcinoma. Both ER and PR were important in predicting the prognosis and directing the treatment of endometrial carcinoma.