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| 比浊法自动测定注射用磺苄西林钠的效价 | |
| 引用本文： | 潘强,王绪,杨雪.比浊法自动测定注射用磺苄西林钠的效价[J].中国药事,2013,27(6):600-603. |
| 作者姓名： | 潘强 王绪 杨雪 |
| 作者单位： | 1. 辽宁省食品药品检验所,沈阳,110023 2. 抚顺市食品药品检验所 3. 辽宁富东制药有限公司 |
| 摘 要： | 目的建立比浊法测定注射用磺苄西林钠效价的方法。方法以金黄色葡萄球菌为试验菌,加菌量为0.5%（V/V）,（37±0.5）℃培养3.5～4.0h测定。结果抗生素最佳线性浓度范围为12.0～25.0U.mL-1,平均回收率为99.9%（n=9）,RSD为1.9%。结论本方法灵敏、快速、实用,可作为测定注射用磺苄西林钠效价的方法。 |
| 关 键 词： | 磺苄西林钠 效价 比浊法 |
Titer of Sulbenicillin Sodium for Injection by Turbidimetric Method |
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| Pan Qiang , Wang Xu , Yang Xue.Titer of Sulbenicillin Sodium for Injection by Turbidimetric Method[J].Chinese Pharmaceutical Affairs,2013,27(6):600-603. | |
| Authors: | Pan Qiang Wang Xu Yang Xue |
| Institution: | (Liaoning Provincial Institute for Food and Drug Control, Shenyang 110023; 1Fushun Institute for Food and Drug Control; 2 Liaoning Fudong Pharmaceutical Co. Ltd.) |
| Abstract: | Objective To establish a turbidimetrie method for the content determination of Sulbenieillin Sodium for Injection. Methods The test organism for the assay was Staphylococcus aureus which was inoculated at 0.5% （V/V） ratio, at （37 ±4 0.5） ℃ for 3.5-4.0 hours. Results The best linear concentration range for antibiotics was 12.0-25.0 U·mL^-1 and the average recovery was 99.9% （n=9）, RSD=1. 9%. Conclusion The method was sensitive, rapid, feasible, and suitable for the content determination of Sulbenicillin Sodium for Injection. |
| Keywords: | Sulbenicillin Sodium titer turbidimetric method |
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