| 蛋白酪氨酸磷酸酶SHP-2研究进展 |
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| 引用本文： | 蔡洪科,邓甬川. 蛋白酪氨酸磷酸酶SHP-2研究进展[J]. 浙江大学学报(医学版), 2012, 41(5): 581-585 |
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| 作者姓名： | 蔡洪科 邓甬川 |
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| 作者单位： | 浙江大学医学院第二附属医院肿瘤外科,浙江杭州,310009 |
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| 摘 要： | SHP-2作为一种蛋白酪氨酸磷酸酶,包含2个SH2结构域,由PTPN11基因编码,参与多种细胞信号转导通路.其突变与不同类型的白血病及实体瘤的发生关系密切.研究SHP-2的作用机制可能会对临床抗肿瘤治疗带来新的希望.
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| 关 键 词： | 蛋白质酪氨酸磷酸酶类/药理学 信号传导 磷酰化 肿瘤 白血病 |
Research progress of protein tyrosine phosphatase SHP-2 |
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| CAI Hong-ke , DENG Yong-chuan. Research progress of protein tyrosine phosphatase SHP-2[J]. Journal of Zhejiang University. Medical sciences, 2012, 41(5): 581-585 |
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| Authors: | CAI Hong-ke DENG Yong-chuan |
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| Affiliation: | (Department of Surgical Oncology,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China) |
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| Abstract: | The Src homology-2 domain-containing phosphatase SHP-2 encoded by PTPN11 is an essential component in several signaling pathways.Different types of mutation in SHP-2 have been confirmed in several types of leukemia and solid tumors.Elucidation of the events underlying Shp2-evoked transformation may provide new insights into the novel targets for anti-cancer therapy. |
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| Keywords: | Protein tyrosine phosphatases/pharmacology Signal transduction Phosphorylation Neoplasms Leukemia |
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